Erythrocyte lipid peroxidation and antioxidants in cigarette smokers

Abstract

The present study has analysed the relationship between lipid peroxidation and antioxidant status in erythrocytes from 30 adult male cigarette smokers and an equal number of age and sex-matched normal subjects. Erythrocyte lipid peroxidation was markedly increased. The enzymic antioxidants were decreased in erythrocytes of cigarette smokers. The present study highlights the occurrence of lipid peroxidation and possible breakdown of antioxidant status in cigarette smoking.

Glutathione, glutathione-dependent enzymes and antioxidant status in gastric carcinoma patients

“…A reason for increased lipid peroxidation in patients with gastric cancer may be a poor enzymatic and non-enzymatic antioxidant defence system. Our study confirmed earlier reports of the evidence for oxidative stress and lipid peroxidation in patients with gastrointestinal tract tumours (Arivazhagan et al 1997, Codandabany 2000, Skrzydlewska et al 2003, Hwang et al 2007, Scibior et al 2008. The impaired antioxidant system may favour accumulation of free radicals.…”

“…Studies have shown that the administration of CAT results in protection against H 2 O 2 -mediated lipid peroxidation. Several studies have shown a decrease in CAT activity in cancer as part of a severe impairment of antioxidant systems in cancerous tissues (Arivazhagan et al 1997, Codandabany 2000. The increase in the erythrocyte lipid peroxidation levels in patients with gastric cancer can be correlated to the reduction in CAT activity.…”

Effect of chronic smoking on lipid peroxidation and antioxidant status in gastric carcinoma patients

“…This may also be due to excessive generation of lipid peroxidation products in tumor tissue, and subsequent release of these products into the circulation. A reason for increased lipid peroxidation in patients with gastric cancer may be a poor enzymatic and non-enzymatic antioxidant defense system [19][20][21][22] . In our study, the extent of plasma lipid peroxidation was markedly higher in gastric cancer patients with smoking than nonsmoking carcinoma patients.…”

“…Studies have shown that the administration of CAT results in protection against H 2 O 2 -mediated lipid peroxidation. Several studies have shown a decrease in CAT activity in cancer as part of a severe impairment of antioxidant systems in cancerous tissues 19,20 . The increase in the erythrocyte lipid peroxidation levels in patients with gastric cancer can be correlated to the reduction in CAT activity.…”

Time course of changes in inflammatory and oxidative biomarkers in lung tissue of mice induced by exposure to electronic cigarette aerosol

“…The activity of GPx was reduced by e-cigarette aerosols exposure for 2 and 4 weeks and activity of catalase was reduced by exposure for 4 weeks. The reduced activity of GPx by conventional cigarette smoke was revealed in humans and animals [36] , [37] , [38] , [39] , [40] . Further, Betsuyaku and colleagues showed that mice that were exposed to repeated cigarette smoke had downregulated catalase in the lungs [41] .…”