Erythrocyte Antioxidant Defense System in Patients with Chronic Renal Failure According to the Hemodialysis Conditions

Prooxidative-Antioxidative Balance of Cells in Different Types of Renal Replacement Therapy

“…Uraemic toxins and highly reactive GPX are also oxidizing substances utilizing GSH [27]. Its concentration in healthy people is significantly higher compared to CKD patients [23,24,25,32,41,44,45]. In the present study PD patients had significantly higher concentrations of GSH than the HD and CKD3-5 groups.…”

“…Other authors also showed that the activity of G6PDH depends on the glucose content in the dialysate. The activity was the highest in the presence of glucose [41,42,43]. …”

One Man’s Meat and Another’s Poison: Adding Glucose in Dialysis Fluid

“…According to findings by the group of Dolegowska [7,8] and others [14] , the hexose monophosphate (HMP) cycle may not be impaired in erythrocytes of HD patients. The HMP pathway can provide reducing equivalents and actively increase antioxidant glutathione (GSH) synthesis during HD therapy.…”

“…Therapeutic potentials provided from variant antioxidants, such as vitamin C [3] , vitamin E [4] , folic acid [5] , and natural products [6] , have been postulated with heartening results in HD patients. Serial studies from Dolegowska's group have focused on the role of glucose and the protective effects of erythrocytes on oxidative stress in the HD population [7][8][9][10] . In this issue [11] , they demonstrated further that glucose present in dialysate could conserve erythrocyte membrane integrity and limit possible hemolysis induced by the HD process.…”

Assessment of microvascular reactivity and oxidative stress in hypertensive adolescents and hemodialysis patients

“…Despite beneficial effects due to the removal of uremic toxins and excess fluid [49], hemodialysis (HD) sessions may themselves induce repetitive bouts of oxidative stress [7,50,51], as indicated by increased levels of MDA and organic hydroperoxides, decreased activities of SOD and GPx, and lower concentrations of selenium, zinc and copper [52]. The dialysis modalities, including the dialysis dose and frequency [49,53], the type of dialysis membrane used [54][55][56], and the presence of glucose in the dialyzing fluid [57], may also affect oxidative stress.…”