Erythematous Annular Plaques in a Necklace Distribution

Meadows, Kappa P.; O'Reilly, Margretta A.; Harris, Ronald M.; Petersen, Marta J.

doi:10.1001/archderm.137.12.1647

Cited by 13 publications

(10 citation statements)

References 7 publications

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“…A papular and arciform variant is also described [90,91]. The histopathologic features are best demonstrated by a biopsy of the elevated edge of the plaque [94]. The lesions may persist for months to years resolving with either mottled pigmentation or normal-appearing skin [95].…”

Section: Annular Elastolytic Giant Cell Granulomamentioning

confidence: 99%

Clinical Manifestations of Sarcoidosis and Granulomatous Disorders

Das¹

2020

Sarcoidosis and Granulomatosis - Diagnosis and Management

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Sarcoidosis is a multisystem granulomatous disease, mainly involving the lungs, mediastinal and peripheral lymph nodes, liver, eyes, and skin. Cutaneous manifestations of sarcoid are variable and behave as "great imitators" of other cutaneous disorders. Cutaneous lesions are classified as specific and nonspecific forms. A large number of systemic sarcoidosis patients have specific cutaneous lesions, and this may be the presenting feature; isolated skin lesions may also present in some patients. Specific lesions of sarcoid are red-brown or red-violaceous in color, asymptomatic, and usually multiple in number. Different types of lesions may present in the same patient. This clinical appearance is due to the presence of epithelioid cell granulomas in the dermis.

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Section: Annular Elastolytic Giant Cell Granulomamentioning

confidence: 99%

Clinical Manifestations of Sarcoidosis and Granulomatous Disorders

Das¹

2020

Sarcoidosis and Granulomatosis - Diagnosis and Management

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“…Although a distinctive intermediate case of annular sarcoidosis of the face was reported to have elastolysis (11), elastophagocytosis and elastolysis are not expected in sarcoidosis, whereas sarcoidosis is mostly diagnosed in younger adults with involvement of other organ systems and laboratory data (9, 10). The abundance of elastotic multinucleated giant cells differentiates AEGCG from granuloma annulare, which is the most similar disease, as well as the absence of mucin deposition, collagen degeneration, and palisading granuloma formation (2, 6, 8, 9). Hence, the present case meets the diagnostic histopathologic criteria for AEGCG.…”

Section: Discussionmentioning

confidence: 99%

“…There are a few cases of AEGCG associated with diabetes mellitus and hypertriglyceridemia (2, 3, 6). Although actinic damage need not be the causative factor in the pathogenesis of AEGCG, the authors concluded that abnormal elastic tissue formation in diabetes mellitus might have contributed in the pathogenesis (3, 6).…”

Section: Discussionmentioning

confidence: 99%

“…Annular elastolytic giant cell granuloma (AEGCG) was first described by Hanke et al as chronic, slowly enlarging annular plaques, showing elastophagocytosis histologically; it has previously been referred to as actinic granuloma, atypical necrobiosis lipoidica, and Miescher's granuloma of the face (1–3). The asymptomatic, flesh‐colored papules and plaques of this rarely seen disease are disfiguring and may persist for years unresponsive to treatment, although spontaneous resolution has been reported (2, 4, 5). The presented case of AEGCG associated with diabetes mellitus is resistant to systemic isotretinoin therapy combined with topical corticosteroids.…”

Section: Introductionmentioning

confidence: 99%

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Lack of Response to Isotretinoin in Annular Elastolytic Giant Cell Granuloma

Başak

Icke

Akkaya

et al. 2004

The Journal of Dermatology

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Annular elastolytic giant cell granuloma is a rare disease characterized by annular configurated lesions with typical histopathologic findings. We report a case of annular elastolytic giant cell granuloma in a 50-year-old male patient. Treatment modalities for this disease are limited and mostly unsatisfactory, although isotretinoin was found to be effective in a single case. However, systemic isotretinoin treatment of 12 weeks' duration was of no benefit in the presented case.

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“…They are characterized by granulomatous infiltrates with multinucleated giant cells in the upper and mid dermis, loss and fragmentation of elastic fibers, and elastophagocytosis by giant cells, without necrobiosis or mucin deposition. These features help to distinguish AEGCG from granuloma annulare and necrobiosis lipoidica, which are the main disorders in the histological differential diagnosis 7 . Association with temporal arteritis is reported 8 .…”

Section: Introductionmentioning

confidence: 99%

Annular Elastolytic Giant Cell Granuloma - A Rare Case with Systemic Involvement

Das¹,

Chowdhury²,

Patra

et al. 2016

Bangladesh J Med Sci

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Abstract:Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous dermatosis characterized by loss of elastic fibers and elastophagocytosis by multinucleated giant cells. It is characterized by annular plaques that are similar to those observed in granuloma annulare but that specifically appear in sun-exposed skin and occurs more commonly in females than males. There have been reported cases of AEGCG associated with diabetes mellitus, systemic sarcoidosis, cutaneous amyloidosis, molluscum contagiosum, squamous cell carcinoma of the lung and cutaneous T-cell lymphoma. We report a case of AEGCG in both sun-exposed as well as covered areas of a middle aged lady with hepatic nodules and Barret's esophagus.

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Erythematous Annular Plaques in a Necklace Distribution

Cited by 13 publications

References 7 publications

Clinical Manifestations of Sarcoidosis and Granulomatous Disorders

Clinical Manifestations of Sarcoidosis and Granulomatous Disorders

Lack of Response to Isotretinoin in Annular Elastolytic Giant Cell Granuloma

Annular Elastolytic Giant Cell Granuloma - A Rare Case with Systemic Involvement

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