1986
DOI: 10.1001/archderm.122.12.1420
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Erythematosquamous skin lesions in hereditary lactate dehydrogenase M-subunit deficiency

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Cited by 13 publications
(17 citation statements)
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“…Furthermore, MCF7 cells (with decreased expression of LDH-B), were highly sensitive to growth inhibition by FX11 [35]. Interestingly studies on naturally occurring LDH-A null patients have shown that such patients do not usually develop symptoms during normal physiological conditions, although excessive fatigue and myoglobulinuria have been noted after intense anaerobic exercise [44]. Taken together with published data, our study provides promising evidence for the possibility that the LDH-A subunit may be a safe 'drugable' target for the development of novel anti-cancer agents [45].…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, MCF7 cells (with decreased expression of LDH-B), were highly sensitive to growth inhibition by FX11 [35]. Interestingly studies on naturally occurring LDH-A null patients have shown that such patients do not usually develop symptoms during normal physiological conditions, although excessive fatigue and myoglobulinuria have been noted after intense anaerobic exercise [44]. Taken together with published data, our study provides promising evidence for the possibility that the LDH-A subunit may be a safe 'drugable' target for the development of novel anti-cancer agents [45].…”
Section: Discussionmentioning
confidence: 99%
“…First, some women experience only mild exercise intolerance but develop prominent uterine stiffness during pregnancy that requires delivery by Cesarean section 106, 108 . Second, muscle LDH deficiency has been associated with an erythematous rash on the extensor surfaces of the extremities which worsens during the summer 105, 109, 110 .…”
Section: Genetic Causes Of Rhabdomyolysismentioning
confidence: 99%
“…Although skin eruptions on the extensor surface of the extremities can act as an important indicator for the detection of this disorder, half the patients have few or no skin lesions. 11 In the majority of patients with this disorder, a definite diagnosis may not be made.…”
Section: Discussionmentioning
confidence: 99%