Erythema induratum of Bazin. Evidence of T-lymphocyte hyperresponsiveness to purified protein derivative of tuberculin: report of two cases and treatment

Ollert, Markus

doi:10.1001/archderm.129.4.469

Cited by 14 publications

(22 citation statements)

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“…Tubercle bacilli are rarely isolated from the tuberculid. However, by polymerase chain reaction, Mycobacterium tuberculosis DNA was identified in 25 18 to 71% 19 of the specimens from erythema induratum of Bazin, and 11 of 22 biopsied specimens (50%) from papulonecrotic tuberculid 20 . The presence of Mycobacterium tuberculosis DNA means not only the presence of bacterial fragments, as has been generally assumed, but also the presence of mycobacteria that are structurally intact to some degree 21 .…”

Section: Discussionmentioning

confidence: 97%

Nodular granulomatous phlebitis of the skin: a fourth type of tuberculid

et al. 1997

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We present five cases of granulomatous phlebitis of the skin and compare them with a case of miliary tuberculosis with granulomatous phlebitis. All five patients were hypersensitive to purified protein derivative, but without active tuberculosis. Although anti-tuberculous drugs were effective, no tubercle bacilli were isolated from the skin. Clinically, subcutaneous nodules were felt along the course of the leg vein. Histologically, epithelioid cell granulomas with Langhans' giant cells were observed within the walls of the cutaneous veins. In a later stage, granulomatous panniculitis was often associated. Using the polymerase chain reaction method. Mycobacterium tuberculosis DNA was detected in four of the five cases of granulomatous phlebitis of the skin. Granulomatous phlebitis of the skin seems to represent a relatively early phase of delayed-type hypersensitivity reactions to Mycobacterium tuberculosis and may represent a distinct entity different from other types of tuberculid-a new tuberculid. Nevertheless, before making the diagnosis, the possibility of true tuberculosis must always be excluded. Nodular granulomatous phlebitis of the skin would be an appropriate name for the newly described condition.

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Section: Discussionmentioning

confidence: 97%

Nodular granulomatous phlebitis of the skin: a fourth type of tuberculid

et al. 1997

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“…In some skin diseases ulceration is a common feature, e.g. vasculitis, panniculitis, periarteritis nodosa, erythema induratum (Bazin), 88…”

Section: Ulcerating Skin Diseasesmentioning

confidence: 99%

Causes, investigation and treatment of leg ulceration

Mekkes¹,

Loots²,

et al. 2003

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Chronic ulceration of the lower leg is a frequent condition, with a prevalence of 3-5% in the population over 65 years of age. The incidence of ulceration is rising as a result of the ageing population and increased risk factors for atherosclerotic occlusion such as smoking, obesity and diabetes. Ulcers can be defined as wounds with a 'full thickness depth' and a 'slow healing tendency'. In general, the slow healing tendency is not simply explained by depth and size, but caused by an underlying pathogenetic factor that needs to be removed to induce healing. The main causes are venous valve insufficiency, lower extremity arterial disease and diabetes. Less frequent conditions are infection, vasculitis, skin malignancies and ulcerating skin diseases such as pyoderma gangrenosum. But even rarer conditions exist, such as the recently discovered combination of vasculitis and hypercoagulability. For a proper treatment of patients with leg ulcers, it is important to be aware of the large differential diagnosis of leg ulceration.

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“…They have reported large series of patients with strong personal and family histories of tuberculosis who had nodules on the legs, who were extremely tuberculin sensitive, and who had complete resolution of skin lesions after adequate antituberculous therapy. Recently, many authors have confirmed these good responses to antituberculous chemotherapy and stressed the need for combination therapy given for a sufficient period (3,4,6,7). Clearance was reported to be quicker in patients treated with combination therapy (17).…”

Section: Discussionmentioning

confidence: 95%

“…However, this condition is frequently encountered in Korea where the incidence of tuberculosis has not declined rapidly. Recently, patients with erythema induratum who had concurrent active pulmonary tuberculosis have been reported in western countries (3,4), and considerable evidence for a tuberculous cause of erythema induratum has been presented from clinical and laboratory investigations (5)(6)(7). We describe three cases of erythema induratum in Korean women with pulmonary tuberculosis.…”

Section: Introductionmentioning

confidence: 94%

Erythema Induratum with Pulmonary Tuberculosis: Report of Three Cases

Cho

Lee

Chun

et al. 1995

The Journal of Dermatology

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Three cases of erythema induratum which occurred in the patients with pulmonary tuberculosis are described. The cutaneous lesions were violaceous, indurated nodules on both lower legs above the malleoli. Histologically, tuberculoid granuloma with caseation necrosis was found in one case; necrotizing vasculitis was the prominent finding in other two cases. The erythema induratum promptly responded to antituberculous therapy. We believe that, in light of these cases, the association between erythema induratum and infection with tubercle bacilli should be re-emphasized.

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Erythema induratum of Bazin. Evidence of T-lymphocyte hyperresponsiveness to purified protein derivative of tuberculin: report of two cases and treatment

Cited by 14 publications

References 0 publications

Nodular granulomatous phlebitis of the skin: a fourth type of tuberculid

Nodular granulomatous phlebitis of the skin: a fourth type of tuberculid

Causes, investigation and treatment of leg ulceration

Erythema Induratum with Pulmonary Tuberculosis: Report of Three Cases

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