Erythema Exudativum Multiforme

Weisberg, Aaron; Rosen, Emanuel

doi:10.1001/archderm.1946.01510310023003

Cited by 20 publications

(3 citation statements)

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“…Evaluation of the extent of GI involvements and histopathological characteristics in SJS/TEN might be obtained by GI tract endoscopy and with biopsy procedures. Hebra and Kaposi first in 1874 ( 15 ) and Osler later in 1895 ( 16 ) described gastrointestinal involvements with visceral manifestations of erythema multiforme, similar to skin lesions. Other endoscopic findings include hyperemia, congestion, irregular friable mucosa, adherent fibrin-like exudate erosions, superficial or deep ulcerations, and necrotic plaque formation with mucosal sloughing ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Carbamazepine-Induced Toxic Epidermal Necrolysis With Clinical Gastrointestinal Involvement: A Case Report

Quynh

Anh

et al. 2022

Front. Pediatr.

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BackgroundStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare and life-threatening disease of the skin and mucosal surfaces. Although gastrointestinal manifestations in adults are potential prognostic factors for disease severity, there are limited data on such cases and their standard management in the pediatric population.Case PresentationWe herein report the case of an 8-year-old girl with a 1-year history of epilepsy, who presented with bilateral conjunctivitis and progressively widespread bullous, and pruritic eruption based on erythematous skin after administration of carbamazepine. A diagnosis of carbamazepine-induced TEN was made, and the drug was immediately discontinued. The result of genetic screening showed that the patient was positive for the HLA-B*15:02 allele. Then, her condition got worse by developing gastrointestinal involvement, including hematemesis and severe watery bloody diarrhea. A combination of the intravenous immunoglobulin and the appropriate dose of systemic steroids have contributed to a favorable outcome in this case. Multidisciplinary care of mucocutaneous involvement, supplemental nutrition, and fluid replacement was also critically warranted. This report aims to contribute to the current literature on TEN-related gastrointestinal manifestations in pediatrics and highlights the need for further investigations in determining the optimal treatment in such cases.ConclusionIn conclusion, we reported the successful treatment of TEN-related gastrointestinal manifestations in a pediatric patient, which should be critically considered in patients with SJS/TEN. Since it may significantly contribute to the poor prognosis of the illness, further investigations in determining standard management in such cases are necessary.

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Section: Discussionmentioning

confidence: 99%

Successful Treatment of Carbamazepine-Induced Toxic Epidermal Necrolysis With Clinical Gastrointestinal Involvement: A Case Report

Quynh

Anh

et al. 2022

Front. Pediatr.

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“…In a boy bearing the clinical features of E. multiforme bullosa, with marked oral and ocular signs, the disease was apparently aggravated by sulphathiazole, and, in fact, this was considered to be the determining factor in the fatal termination. Nicotinic acid therapy is considered favourably by Weisberg and Rosen (1946). The photographs in this paper were taken by Mr. J. Gregory Williamson, to whom I am extremely grateful.…”

Section: Archives Of Disease In Chlldhoodmentioning

confidence: 99%