Erythema chronicum migrans

Scrimenti, R. J.

doi:10.1001/archderm.102.1.104

Cited by 47 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tyzzer's focus on infections of small rodents would appear to be remarkably prescient in the context of "emerging diseases." We now know that his Cryptosporidium parvum (29) (35) was described and is also the site where the first upper midwestern cases of human babesiosis due to Ba. microti emerged (36).…”

Section: Resultsmentioning

confidence: 99%

Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle.

Telford

Dawson

Katavolos

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

460

371

View full text Add to dashboard Cite

Propagation of the Agent of HGE. Blood (EDTA anticoagulated) was obtained from a Nantucket patient with HGE whose infection was confirmed by blood smear and sequencing of a 16S rDNA amplification product (8), and 0.5 ml was inoculated i.p. into a splenectomized CD-1 mouse. Buffy coat preparations (equivalent to 1 ml of whole blood, centrifuged at 2500 x g for 10 min) were inoculated i.p. into two intact C3H/HeJ mice. Plasma (0.5 ml) was inoculated into one C3H/HeJ mouse as well. To determine whether ehrlichiae were present in the peripheral blood, thin blood smears were taken from the tails of rodents, dried, fixed for 2 min in absolute methanol, and stained with 1 ml Giemsa stock (Harleco Original Azure Blend; EM Diagnostic Systems, Princeton, NJ) diluted in 40 ml distilled water with 150 ptl of 0.5% Na2CO3 and 1.25 ml methanol for 1 hr or more (9

show abstract

Section: Resultsmentioning

confidence: 99%

Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle.

Telford

Dawson

Katavolos

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

460

371

View full text Add to dashboard Cite

show abstract

“…However, the first described case in the US was reported from Wisconsin in 1970, before the disease was formally recognized (3). Over the past few decades, Lyme disease has spread from these initial foci to affect large areas of the Northeast and Midwest, with Ͼ27,000 cases reported from these regions in 2007 (4).…”

mentioning

confidence: 99%

Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events

Hoen

Margos

Bent

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

151

179

View full text Add to dashboard Cite

Since its first description in coastal Connecticut in 1976, both the incidence of Lyme disease and the geographic extent of endemic areas in the US have increased dramatically. The rapid expansion of Lyme disease into its current distribution in the eastern half of the US has been due to the range expansion of the tick vector, Ixodes scapularis, upon which the causative agent, Borrelia burgdorferi is dependent for transmission to humans. In this study, we examined the phylogeographic population structure of B. burgdorferi throughout the range of I. scapularis-borne Lyme disease using multilocus sequence typing based on bacterial housekeeping genes. We show that B. burgdorferi populations from the Northeast and Midwest are genetically distinct, but phylogenetically related. Our findings provide strong evidence of prehistoric population size expansion and east-to-west radiation of descendent clones from founding sequence types in the Northeast. Estimates of the time scale of divergence of northeastern and midwestern populations suggest that B. burgdorferi was present in these regions of North America many thousands of years before European settlements. We conclude that B. burgdorferi populations have recently reemerged independently out of separate relict foci, where they have persisted since precolonial times.geography ͉ phylogeny ͉ ticks ͉ multilocus sequence typing

show abstract

“…Wisconsin). Based on the European literature, Scrimenti successfully treated the patient with penicillin (Scrimenti, 1970). Five years later, a mysterious outbreak of what originally appeared to be juvenile rheumatoid arthritis was reported among children from three towns in southeastern Connecticut, including the towns Lyme and Old Lyme.…”

Section: Short Review Of the Long History Of Lyme Borreliosismentioning

confidence: 99%

A STING from a Tick : Epidemiology, Ecology and Clinical Aspects of Lyme Borreliosis

Wilhelmsson¹

2014

View full text Add to dashboard Cite

Erythema chronicum migrans

Cited by 47 publications

References 0 publications

Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle.

Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle.

Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events

A STING from a Tick : Epidemiology, Ecology and Clinical Aspects of Lyme Borreliosis

Contact Info

Product

Resources

About