2014
DOI: 10.18632/aging.100695
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Abstract: A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative diseases. In the current work, we focus on inflammatory signalling in PD, using a systems approach that allows us to look at the disease in a more holistic way. We discuss cyclooxygenases, prostag… Show more

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Cited by 73 publications
(77 citation statements)
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References 313 publications
(288 reference statements)
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“…The adherence of eryptotic cells to vascular wall endothelial CXCL16/SR-PSO [61] and the binding of phosphatidylserine-exposing erythrocytes to blood platelets could further stimulate blood clotting and trigger thrombosis [62]. Eryptosis could also be induced by a wide range of xenobiotics [63-74], and enhanced eryptosis is observed in several clinical conditions, such as systemic lupus erythematosus [75], uremia under hemodialysis or peritoneal dialysis [76], pulmonary tumor [77], Parkinson’s disease [78], arteritis [79], hepatic failure [80, 81], tumor-induced anemia [82], vitamin D excess [83], advanced age [84], G6PD deficiency [85], sepsis [86], APC gene mutation and colon carcinoma [87]. Eryptosis can also be triggered by erythrocyte storage [88-90].…”
Section: Discussionmentioning
confidence: 99%
“…The Annexin V signals seen in this study might be due to the increase in influx of Ca 2+ into the erythrocytes, activation of the Ca 2+ /K + channels and ATP depletion that are initiated by oxidative stress caused by the Cr and to lessor degree Cd [11, 34, 35, 45]. The increase in cytosolic Ca 2+ will activate scramblase in the erythrocytes, which inhibits flippase that in turn causes floppase to translocate PS to the outside, resulting in the PS flip and membrane scrambling (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…In erythrocytes this process is known as eryptosis [5-11]. Characteristic features of this process are cell membrane shrinkage as well as blebbing and membrane scrambling [11].…”
Section: Introductionmentioning
confidence: 99%
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