Eruptive xanthomas associated with isotretinoin (13-cis-retinoic acid)

Dicken, C. H.

doi:10.1001/archderm.116.8.951

Cited by 24 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whereas levels as high as this are occasionally seen in patients on isotretinoin, these are usually in patients with pre-existing hyperlipidaemia. There is only I case of acute pancreatitis due to isotretinoin reported in the literature (Shalita 1987), and I case of eruptive xanthoma developing in a patient on isotretinoin within 2 rrlonths of starting treatment (Dicken & Connoly 1980).…”

Section: Effects On Lipid Metabolismmentioning

confidence: 99%

Adverse Reactions to Oral Retinoids An Update

Mills

Marks

1993

Drug Safety

View full text Add to dashboard Cite

Retinoids, both naturally occurring and synthetic, are analogues of vitamin A. They represent a major advance in the treatment of acne and psoriasis, as well as rarer conditions such as the ichthyoses. The more frequent and widespread use of these drugs requires that the dermatologist be aware of the wide spectrum of adverse events that may be encountered with their use. Some are serious and irreversible, such as teratogenicity, necessitating great care if these drugs are given to women of childbearing potential. Other effects may be less severe, dose dependent and reversible. Although not devastating to the patient, appropriate advice may reduce morbidity.

show abstract

Section: Effects On Lipid Metabolismmentioning

confidence: 99%

Adverse Reactions to Oral Retinoids An Update

Mills

Marks

1993

Drug Safety

View full text Add to dashboard Cite

show abstract

“…Zegarelli et al (9) have speculated that verruciform xanthoma is inflammatory in origin. Abnormalities of lipoprotein metabolism may be important (10)(11)(12), but as in our patient, lipid metabolism and serum lipid levels are usually normal (8). A viral etiology is unproven (13,14).…”

Section: Discussionmentioning

confidence: 85%

Recurrent Verruciform Xanthoma of the Vulva

Reich

Regauer²

2004

International Journal of Gynecological Pathology

View full text Add to dashboard Cite

Verruciform xanthoma is a rare, benign, mucocutaneous, nondestructive lesion characterized by proliferation of non-Langerhans lipid-rich histiocytes. We describe the clinical and pathologic findings in a 30-year-old female with recurrent verruciform xanthoma of the vulva 8 years after initial therapy. The differential diagnosis includes seborrheic keratosis, verruca simplex, condyloma acuminatum, granular cell myoblastoma, vulvar intraepithelial neoplasia, bowenoid papulosis, erythroplasia of Queyrat, and verrucous carcinoma.

show abstract

“…Glyburide, an insulin-releasing agent, was able to clear the xanthomas in a short time despite continued olanzapine therapy, which is is certainly consistent with olanzapine acting on the pancreas. 28 The present series adds to the list of drugs associated with eruptive xanthoma due to hypertriglyceridemia, incuding isotretinoin 29 and indomethacin. 30 The frequency of dyslipidemia with the use of clozapine and olanzapine appears to be relatively high (about 30%) and may explain the appearance of eruptive xanthomas.…”

Section: Commentmentioning

confidence: 97%