Eruptive melanocytic nevi with malignant transformations and the connection to BRAF and p16 mutations

A case of eruptive melanocytic nevi in an 8-year-old healthy boy

“…7 Nevertheless, given the unusual and poorly understood phenomenon of EMN with possible underlying genetic mutation link, regular annual screening for dysplastic nevi and melanoma is recommended. 4 Fig 5 . Melanocytes exhibited heavily pigmented cytoplasm but no cytologic atypia. There was a brisk inflammatory cell infiltrate associated with the nevus with numerous, heavily pigmented melanophages.…”

“…3 There are no clear predisposing factors, but reported associations include diminished immune surveillance, genetic susceptibility, and adverse drug effects. 4,5 Furthermore, various triggers including light exposure, cutaneous injury, bullous dermatoses, biologic chemotherapeutics, increased hormone levels, atopic dermatitis, postoperative fever, and seizures were implicated. 1…”