Eruptive Keratoacanthomas in a New Tattoo

Chorny, Joe A.

doi:10.1001/archderm.143.11.1457

Cited by 31 publications

(21 citation statements)

References 8 publications

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“…In this review, we found 24 reported cases of squamous neoplasms arising within tattoos (Table ) . These lesions often present as an enlarging, erythematous papule or nodule that may have associated ulceration, scale, induration, or central keratinaceous material .…”

Section: Clinical Presentationmentioning

confidence: 99%

“…These lesions often present as an enlarging, erythematous papule or nodule that may have associated ulceration, scale, induration, or central keratinaceous material . Solitary nodules are most common, but multiple lesions at initial presentation or developing over time have also been described . This phenomenon has been reported to occur in patients with ages ranging from 24 to 79 years .…”

Section: Clinical Presentationmentioning

confidence: 99%

“…The age of the tattoo at the time of presentation may vary from weeks to > 50 years after tattoo placement . The majority of the reported cases were seen in men (15 men, 8 women, 2 sex unknown), and lesions were primarily located on the extremities …”

Section: Clinical Presentationmentioning

confidence: 99%

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Squamous neoplasms arising within tattoos: clinical presentation, histopathology and management

2017

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Tattooing, which involves the placement of ink into the skin, is an ancient decorative technique that has remained popular in modern society. Tattoos have long been known to cause cutaneous reactions, which include the emergence of neoplasms such as keratoacanthoma (KA) and squamous cell carcinoma (SCC) in tattooed areas of the skin. We review the clinical presentations, histology and treatment options for squamous neoplasms, primarily KA and SCC, arising in tattoos.

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Section: Clinical Presentationmentioning

confidence: 99%

Section: Clinical Presentationmentioning

confidence: 99%

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Squamous neoplasms arising within tattoos: clinical presentation, histopathology and management

2017

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“…In addition to trauma, many inflammatory conditions or diseases have been described repeatedly as causative events for KA formation. One example is tattoo‐associated KAs . Development of KAs in tattoos is almost always associated with red ink (mercury sulphide).…”

Section: Reactive Kasmentioning

confidence: 99%

Squamous cell carcinoma and keratoacanthomas are biologically distinct and can be diagnosed by light microscopy: a review

et al. 2016

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Keratoacanthomas (KAs) are self-limiting squamoproliferative lesions usually seen on sun damaged skin. These tumours are in many ways enigmatic, and the relation between KAs and squamous cell carcinoma is still a contested topic. In this review the biology and histology of KAs will be discussed, and based on morphology, clinical outcome and recent genetic analysis of the tumour types, we conclude that KAs and SCCs are two distinct biological entities which can usually be distinguished by conventional microscopy. The sentinel observation of rapid and frequent appearance of KAs after BRAF treatment of malignant melanoma patients has paved the way for a more general understanding of the pathogenesis leading to the appearance of KAs in patients with inflammation in the skin. In BRAF treated patients, the KAs are a consequence of paradoxical activation of the MAP kinase pathway. Similarly, any external trauma or pharmaceutical interventions resulting in inflammation in the skin will activate the MAP kinase pathway. Such inflammation-mediated MAP kinase activation in the skin will result in the development of KAs through the same pathway as demonstrated for BRAF treated patients. It is characteristic that skin tumours following short acting inflammatory stimulation of severely sun damaged skin develop almost exclusively into KAs, whereas it is exceedingly rare that such inflammatory conditions lead to formation of SCCs. The understanding that inflammatory reactions in sun-damaged skin may activate pathways specifically leading to the formation of KAs may spare the patient the discomfort and disfigurement of needless overtreatment.

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“…17 The development of eruptive KA in altered skin has been documented many times previously. Surgical trauma, chemical peels, ablative laser, thermal burns, cryotherapy, tattoos, megavoltage radiotherapy, phototherapy, vaccinations, photodynamic therapy (PDT), and now imiquimod, have all being associated with solitary or eruptive KA [3][4][5][6][7][18][19][20][21][22] . Inflammation appears to be the unifying feature, but how this leads to KA formation remains speculative.…”

Section: Discussionmentioning

confidence: 99%

Eruptive keratoacanthoma and squamous cell carcinoma complicating imiquimod therapy: Response to oral acitretin

Foxton

Delaney

2010

Australasian Journal of Dermatology

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An 87-year-old woman with eruptive keratoacanthomas complicating recent imiquimod therapy is presented. Lesions developed both at and distal to the treatment site. She responded well to 8 weeks of oral acitretin with resolution of most lesions and no recurrence at 6 months post treatment. A remaining lesion was excised and found to be a well-differentiated squamous cell carcinoma. Keratoacanthoma and squamous cell carcinoma should be considered in any patient developing rapidly growing keratotic nodules in association with recent imiquimod therapy. The aetiology and treatment of eruptive keratoacanthomas is briefly discussed.

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Eruptive Keratoacanthomas in a New Tattoo

Cited by 31 publications

References 8 publications

Squamous neoplasms arising within tattoos: clinical presentation, histopathology and management

Squamous neoplasms arising within tattoos: clinical presentation, histopathology and management

Squamous cell carcinoma and keratoacanthomas are biologically distinct and can be diagnosed by light microscopy: a review

Eruptive keratoacanthoma and squamous cell carcinoma complicating imiquimod therapy: Response to oral acitretin

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