Eruptive dysplastic nevi associated with human immunodeficiency virus infection

Duvic, M.

doi:10.1001/archderm.125.3.397

Cited by 32 publications

(19 citation statements)

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“…Such a mechanism was proposed on the basis of histopathologic evidence of a precursor nevus in all 10 evaluable primary tumors from an international case series of melanomas arising in transplant recipients (4), a finding that has not been replicated in two recent, small case series (34,35). This observation and hypothesis is supported by case reports of eruptive melanocytic nevi shortly after the onset of immunosuppression, whether it be iatrogenic (7,36,37), HIV-related (8,38), or chemotherapy-related (6,9,39).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Melanoma Is Related to Immune Suppression in Kidney Transplant Recipients

Vajdic

Leeuwen

Webster

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Melanoma incidence is increased after organ transplantation, but there is uncertainty as to why this occurs. Diagnoses of invasive melanoma were ascertained in 8,152 kidney transplant recipients by linking national Australian population-based registers, the Australia and New Zealand Dialysis and Transplant Registry, and the Australian National Cancer Statistics Clearing House. Incidence rate ratios (IRR) and standardized incidence ratios were used to compare melanoma risk during periods of transplant function and failure. Standardized incidence ratios were also computed by time since transplantation. Risk factors were examined using multivariate Poisson regression. Linkage identified 82 melanomas (134/100,000 person-years). Incidence was lower after resumption of dialysis and reduction of immune suppression than during transplant function [IRR, 0.09; 95% confidence interval (95% CI), 0.01-0.66]. During first transplant function, melanoma (n = 74) relative risk peaked in the second year and declined linearly thereafter (P trend = 0.03). During first transplant function, risk was positively associated with increasing year of age (IRR, 1.05; 95% CI, 1.03-1.07) and receipt of lymphocyte-depleting antibody (IRR, 1.73; 95% CI, 1.05-2.84). Female sex (IRR, 0.57; 95% CI, 0.35-0.94), non-Caucasian race (IRR, 0.15; 95% CI, 0.02-1.05), and increasing time since transplantation (P trend = 0.06) were inversely associated with risk. The incidence pattern and risk factor profile for melanoma after transplantation strongly suggest that the current receipt, intensity, and possibly the recency of iatrogenic immunosuppression increase melanoma risk. Melanoma risk was also associated with proxy indicators of high personal sun exposure and sensitivity. These findings show the marked influence of immunologic control over melanoma incidence. (Cancer Epidemiol Biomarkers Prev 2009;18(8):2297-303)

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Section: Discussionmentioning

confidence: 99%

Cutaneous Melanoma Is Related to Immune Suppression in Kidney Transplant Recipients

Vajdic

Leeuwen

Webster

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…With the former, eruptive MN have been reported in patients with erythema multiforme, 3 Stevens-Johnson syndrome, [4][5][6] toxic epidermal necrolysis, [3][4][5]7 epidermolysis bullosa, 8,9 and bullae induced by mustard gas. 10 There have also been reports of eruptive nevi arising in patients with immunosuppression from human immunodeficiency virus infection, 11,12 neoplastic disease, 13,14 organ transplantation, 15,16 Crohn disease, [17][18][19] or chemotherapy. 20 Eruptive MN have been described less frequently in association with Addison disease 21 and psoralen-UV-A phototherapy.…”

Section: Arch Dermatol 2007;143(12):1555-1557mentioning

confidence: 99%

“…Several researchers believe that an intact immune system normally limits the proliferation of melanocytes, whereas a disordered one is unable to do so, leading to eruptive MN. 5,12,13,15,18,19,27 To support this concept, Piaserico et al 15 recently described fading and disappearance of eruptive MN on withdrawal of immunosuppressive therapy in a renal transplant recipient who was experiencing graft rejection. As other researchers 25 have suggested, it seems that immunodeficiency itself, not the type of immunosuppression, plays a pivotal role in the development of eruptive MN.…”

Section: Commentmentioning

confidence: 99%

Long-term Follow-up of a Patient With Eruptive Melanocytic Nevi After Stevens-Johnson Syndrome

Gelfer¹,

Rivers²

2007

Arch Dermatol

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“…Three were dysplastic nevus, but malignant transformation was not observed during the one-year period. However, multiple nevi may be a sign of immunosuppression [9].…”

Section: Discussionmentioning

confidence: 99%

Dermatological Findings in Turkish Paediatric Haematology-Oncology Patients

Ukşal

Öztürk²,

Çölgeçen

et al. 2016

Eurasian J Med

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Objective: Diagnoses of skin, mucosae, hair and nail manifestations in malignant diseases are often challenging because of life-threatening drug reactions, opportunistic infections or skin involvement of primary processes. Description of morphology, configuration and distribution of lesions is important in order to differentiate the self-healing eruptions from serious side effects of chemotherapy. There are case reports from Turkey including dermatological manifestations of malignancies and case series in adult patients but there are no published large group studies assessing all manifestations in children. The aim of this study was to evaluate the morphological features of dermatological findings in children with haemato-oncological diseases. Materials and Methods: The study was performed at the Erciyes University, Faculty of Medicine Pediatric Hematology-Oncology Clinic, Turkey. Three dermatologists daily consulted all patients admitted to the clinic during a one-year period. Results: The study group comprised of 157 children (79 female/78 male) aged 1-16 years (mean 7.19±4.63). Detailed dermatological examinations were performed, including oral-genital mucosae, hair and nails. Thorough skin examination revealed that 70% of the patients exhibited at least one dermatological finding. Generalized xerosis and hyperpigmentation were the most common findings among patients undergoing chemotherapy (24.19%). Multiple nevi on at least 10 covered areas were very frequent among patients undergoing long-term chemotherapy (18.47%). Three were identified as dysplastic nevus, but malignant transformation was not observed during the one-year study period. Conclusion: Regular dermatological consultation may help resolve the diagnostic and therapeutic problems in paediatric haemato-oncology clinics.

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Eruptive dysplastic nevi associated with human immunodeficiency virus infection

Cited by 32 publications

References 0 publications

Cutaneous Melanoma Is Related to Immune Suppression in Kidney Transplant Recipients

Cutaneous Melanoma Is Related to Immune Suppression in Kidney Transplant Recipients

Long-term Follow-up of a Patient With Eruptive Melanocytic Nevi After Stevens-Johnson Syndrome

Dermatological Findings in Turkish Paediatric Haematology-Oncology Patients

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