Erratum to "Growth cone form, behavior, and interactions in vivo: Retinal axon pathfinding as a model"

Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish

“…Consistent with previous studies (Bovolenta and Mason, 1987;Chan et al, 1998;Hutson and Chien, 2002;Mason and Erskine, 2000;Mason and Wang, 1997), control growth cones projecting toward the midline displayed a simple, streamlined shape with short filopodia extending from the leading edge of the growth cone (Fig. 4A, see Movie 1 in the supplementary material).…”

Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish

“…Consistent with previous studies (Bovolenta and Mason, 1987;Chan et al, 1998;Hutson and Chien, 2002;Mason and Erskine, 2000;Mason and Wang, 1997), control growth cones projecting toward the midline displayed a simple, streamlined shape with short filopodia extending from the leading edge of the growth cone (Fig. 4A, see Movie 1 in the supplementary material).…”

Effects of substrate geometry on growth cone behavior and axon branching

“…Had our recordings continued for a longer time, we may well have observed formation of a collateral branch in these latter cases. In sum, studies of axons at node intersections are consistent with the hypothesis that a pause in outgrowth leads first to changes in growth cone shape and later to the formation of collateral branches (Szenbenyi et al, 1998;Kalil et al, 2000;Mason and Erskine, 2000). The novel aspect of the present study is that it shows that these effects can be induced simply by changes in substrate geometry.…”

Growth Cone Pathfinding: a competition between deterministic and stochastic events

“…We have reproduced, with a very simple model, stereotypical behavior seen in vitro [25,26,34,38]. Consistent with observed migratory behavior [23,39-42], our computational model predicts two primary migrational states based upon simple stochastic and deterministic behavioral dynamics. To calculate which migrational state the growth cone is within, we have defined a dimensionless measure, the determinism ratio Ψ, that captures the balance between stochastic and deterministic motions driving migration.…”

Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish

“…Consistent with previous studies (Bovolenta and Mason, 1987;Chan et al, 1998;Hutson and Chien, 2002;Mason and Erskine, 2000;Mason and Wang, 1997), control growth cones projecting toward the midline displayed a simple, streamlined shape with short filopodia extending from the leading edge of the growth cone (Fig. 4A, see Movie 1 in the supplementary material).…”

Effects of substrate geometry on growth cone behavior and axon branching

“…Had our recordings continued for a longer time, we may well have observed formation of a collateral branch in these latter cases. In sum, studies of axons at node intersections are consistent with the hypothesis that a pause in outgrowth leads first to changes in growth cone shape and later to the formation of collateral branches (Szenbenyi et al, 1998;Kalil et al, 2000;Mason and Erskine, 2000). The novel aspect of the present study is that it shows that these effects can be induced simply by changes in substrate geometry.…”

Growth Cone Pathfinding: a competition between deterministic and stochastic events

“…We have reproduced, with a very simple model, stereotypical behavior seen in vitro [25,26,34,38]. Consistent with observed migratory behavior [23,39-42], our computational model predicts two primary migrational states based upon simple stochastic and deterministic behavioral dynamics. To calculate which migrational state the growth cone is within, we have defined a dimensionless measure, the determinism ratio Ψ, that captures the balance between stochastic and deterministic motions driving migration.…”

Semaphorin 3d guides laterality of retinal ganglion cell projections in zebrafish

“…Consistent with previous studies (Bovolenta and Mason, 1987;Chan et al, 1998;Hutson and Chien, 2002;Mason and Erskine, 2000;Mason and Wang, 1997), control growth cones projecting toward the midline displayed a simple, streamlined shape with short filopodia extending from the leading edge of the growth cone (Fig. 4A, see Movie 1 in the supplementary material).…”

Effects of substrate geometry on growth cone behavior and axon branching

“…Had our recordings continued for a longer time, we may well have observed formation of a collateral branch in these latter cases. In sum, studies of axons at node intersections are consistent with the hypothesis that a pause in outgrowth leads first to changes in growth cone shape and later to the formation of collateral branches (Szenbenyi et al, 1998;Kalil et al, 2000;Mason and Erskine, 2000). The novel aspect of the present study is that it shows that these effects can be induced simply by changes in substrate geometry.…”

Growth Cone Pathfinding: a competition between deterministic and stochastic events

“…We have reproduced, with a very simple model, stereotypical behavior seen in vitro [25,26,34,38]. Consistent with observed migratory behavior [23,39-42], our computational model predicts two primary migrational states based upon simple stochastic and deterministic behavioral dynamics. To calculate which migrational state the growth cone is within, we have defined a dimensionless measure, the determinism ratio Ψ, that captures the balance between stochastic and deterministic motions driving migration.…”