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Cited by 3 publications
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“…In our study, we showed that the results of meldonium treatment, including the in vivo effects, were coupled to PGC‐1α or its orthologue Spargel ( srl ) gene overexpression. We might explain the same normalization of mitochondrial dynamics by the increase of PGC‐1α expression, which in turn induces a balanced expression of fusion/fission genes by binding to their promoters and implying its direct role in the regulation of mitochondrial dynamics (Dabrowska et al, ). Future studies should clarify whether PPARγ activation mediates the PGC‐1α elevation induced by meldonium or is related to other PPAR‐independent mechanisms.…”
Section: Discussionmentioning
confidence: 86%
“…In our study, we showed that the results of meldonium treatment, including the in vivo effects, were coupled to PGC‐1α or its orthologue Spargel ( srl ) gene overexpression. We might explain the same normalization of mitochondrial dynamics by the increase of PGC‐1α expression, which in turn induces a balanced expression of fusion/fission genes by binding to their promoters and implying its direct role in the regulation of mitochondrial dynamics (Dabrowska et al, ). Future studies should clarify whether PPARγ activation mediates the PGC‐1α elevation induced by meldonium or is related to other PPAR‐independent mechanisms.…”
Section: Discussionmentioning
confidence: 86%
“…Hypoxia inducible factor-1α (HIF-1α), the transcriptional regulator that responds to hypoxia, has been reported to negatively modulate mitochondrial dynamics by promoting the expression of Drp1 (Chen et al, 2019). In addition, HIF-1α has been reported to inhibit the expression of Mfn2, which directly or indirectly influences mitochondrial function (Martin et al, 2014;Dabrowska et al, 2015).…”
Section: Introductionmentioning
confidence: 99%