Erratum: Jung, S., et al. Cluster-Based Analysis of Infectious Disease Occurrences Using Tensor Decomposition: A Case Study of South Korea. Int. J. Environ. Res. Public Health 2020, 17, 4872

Jung, Seung-Won; Moon, Jaeuk; Hwang, Eenjun

doi:10.3390/ijerph17249493

Cited by 3 publications

(1 citation statement)

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“…Along with the mortality and disability, the continued illness results in lengthier hospitalization, the necessity for more affluent medicines, and monetary encounters for individuals affected [6,7]. Therefore, it is true that deprived of active antimicrobials, the accomplishment of modern medicines, mainly in treating infections, including at the time of chemotherapy and major surgery, would be in augmented danger [8].…”

Section: Introductionmentioning

confidence: 99%

Novel pyrazole‐biphenyl‐carboxamides for SARS‐CoV2 entry‐level restriction and microbial infections

Samy,

Dangate,

Alagumuthu

2024

Journal of Heterocyclic Chem

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Microbial diseases including viral infection are big issues globally. Effective medicinal discovery for them is the need for the day. In this study, we report pyrazole‐biphenyl‐carboxamides (4a‐l) validated for their SARS‐CoV2 entry‐level restriction effect over studying the protein–protein interaction of SARS‐CoV2 with human ACE protein. Their extended antimicrobial properties were also evaluated. Online and offline software tools predicted MD simulation and ADMET druggability in silico. The antimicrobial efficacy of all compounds was also evaluated against Gram+ve Streptococcus pneumoniae (MTCC 1936), Staphylococcus aureus (MTCC 737) and Gram‐ve Escherichia coli (MTCC 443), Pseudomonas aeruginosa (MTCC 424) (bacteria). In the results, compounds 4g and 4i were evenly active against both bacteria at a low concentration range (MIC: 1.00 to 9.5 μg/mL) and displayed lesser toxicity to tested mammalian cells (EC100 = 75 μg/mL). Furthermore, it was able to kill metabolically inactive bacterial cells and eradicate established biofilms of Methicillin‐resistant Staphylococcus aureus (MRSA). Both the compounds inhibited DNA gyrase well with an IC50 0.25 μM (96% relative activity) and 0.52 μM (97% relative activity) respectively. Compounds (4a‐l) showed restrictive efficiency of SARS‐CoV2 spike protein (SC2SP) and human angiotensin‐converting enzyme 2 (hACE2) entry‐level association in COVID‐19 in silico. To assess this ability, firstly, we identified the crucial amino acid residues involved in the interface of SARS‐CoV‐2 and hACE2 virtually. We recognized the ability of 4a‐l binding to the binding interface to SARS‐CoV2; thus, the interaction of SC2SP‐hACE2 was effectively inhibited.

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Section: Introductionmentioning

confidence: 99%