Erratum: Bioactive acylphloroglucinols from <i>Hypericum densiflorum</i>

Henry, Geneive E.; Campbell, Matthew S.; Zelinsky, Ashlee A.; Liu, Yun‐Bao; Bowen-Forbes, Camile S.; Li, Liya; Nair, Muraleedharan G.; Rowley, David; Seeram, Navindra P.

doi:10.1002/ptr.3264

Cited by 3 publications

(6 citation statements)

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“…The results of these studies add to growing knowledge of the antimicrobial properties of acylphloroglucinol metabolites. Other studies have reported acylphloroglucinol derivatives possessing antimicrobial activity against staphylococci (Ishiguro et al ., ; Schempp et al ., ; Winkelmann et al ., , ; Gibbons et al ., ; Pecchio et al ., ; Henry et al ., ). A study by Socolsky et al .…”

Section: Resultsmentioning

confidence: 97%

“…Compounds 3 (54.7 mg) and 4 (36.9 mg) were isolated from a hexanes extract of the aerial portions of H. densiflorum , whereas compound 5 (110.4 mg) was isolated from an acetone extract of the same plant. The structures were confirmed on the basis of NMR spectroscopic data (Henry et al ., ). Compound 4 had been previously reported from H. olympicum and prepared by synthesis (Gibbons et al ., ), and compound 5 was recently isolated from H. elegans (Nedialkov et al ., ).…”

Section: Methodsmentioning

confidence: 97%

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Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Sarkisian

Janssen

Matta

et al. 2011

Phytotherapy Research

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Biofilm embedded bacterial pathogens such as Staphylococcus spp., Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii are difficult to eradicate and are major sources of bacterial infections. New drugs are needed to combat these pathogens. Hypericum is a plant genus that contains species known to have antimicrobial properties. However, the specific constituents responsible for the antimicrobial properties are not entirely known, nor have most compounds been tested as inhibitors of biofilm development. The investigation presented here tested seven secondary metabolites isolated from the species Hypericum densiflorum, Hypericumellipticum, Hypericum prolificum and Hypericum punctatum as inhibitors of bacterial growth and biofilm production. Assays were conducted against Staphylococcus epidermidis, Staphylococcusaureus, clinical methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii. Five of the seven compounds demonstrated growth inhibition against the Gram-positive bacteria with minimum inhibitory concentrations (MIC) ranging from 1.95 μg/mL to 7.81 μg/mL. Four of the secondary metabolites inhibited biofilm production by certain Gram-positive strains at sub-MIC concentrations.

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Section: Resultsmentioning

confidence: 97%

Section: Methodsmentioning

confidence: 97%

Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Sarkisian

Janssen

Matta

et al. 2011

Phytotherapy Research

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“…Not all Hypericum species contain significant amount of phloroglucinols, which have been found in H. densiflorum, H. chinence, H. balearicum , and H. empetrifolium , etc. (Crockett et al, 2008; Henry et al, 2009; Tanaka et al, 2009). However, the existence of this group of relatively less studied anti-inflammatory constituents in certain Hypericum species, especially H. gentianoides as shown in the current study, could account for a part of the observed differences among the species in their anti-inflammatory potentials.…”

Section: Discussionmentioning

confidence: 99%

“…Besides H. perforatum , other species of the Hypericum genus are being studied to identify their constituents, as well as anti-inflammatory, anti-proliferation, and anti-microbial activities (Crockett et al, 2008; Henry et al, 2009; Kartnig et al, 1996). Among these species, a more lipophilic fraction of H. gentianoides methanol extract, rich in acylphloroglucinols, was found to have potent inhibitory effect on LPS-induced macrophage production of prostaglandin E2 (PGE2) (Hillwig et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages

et al. 2011

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Hypericum perforatum (St. John’s wort) is an herb widely used as supplement for mild to moderate depression. Our prior studies revealed synergistic anti-inflammatory activity associated with 4 bioactive compounds in a fraction of H. perforatum ethanol extract. Whether these 4 compounds also contributed to the ethanol extract activity was addressed in the research reported here. Despite the popularity of H. perforatum, other Hypericum species with different phytochemical profiles could have their anti-inflammatory potentials attributed to these or other compounds. In the current study, ethanol extracts of different Hypericum species were compared for their inhibitory effect on LPS-induced prostaglandin E2 (PGE2) and nitric oxide (NO) production in RAW 264.7 mouse macrophages. Among these extracts, those made from H. perforatum and H. gentianoides demonstrated stronger overall efficacy. LC-MS analysis indicated the 4 compounds in H. perforatum extract and pseudohypericin in all active fractions. The 4 compounds accounted for a significant part of the extract’s inhibitory activity on PGE2, NO, tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) in RAW 264.7 as well as peritoneal macrophages. Pseudohypericin was the most important contributor of the anti-inflammatory potential among the 4 compounds. The lipophilic fractions of H. gentianoides extract, which did not contain the previously identified active constituents, decreased PGE2 and NO potently. These fractions were rich in acylphloroglucinols, including uliginosin A that accounted for a proportion of the anti-inflammatory activity observed with the active fractions. Overall, the current study revealed a different group of major anti-inflammatory constituents in H. gentianoides, while showing that a previously identified 4 compounds combination was important for H. perforatum’s anti-inflammatory potential.

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“…Distributed in 30 genera, the plants of the Clusiaceae family include economically relevant trees, shrubs, lianas and herbs used in the production of edible fruit, hardwood and chemical derivatives with interesting pharmacological and industrial properties [1][2][3]. More specifically, the plants of the Platonia genus are rich in natural products with relevant biological activities [4,5], such as antimicrobial [6], leishmanicidal [7], antidepressant [8,9], cytotoxic [10], anti-HIV [11], anti-inflammatory [12], anticonvulsant [13] and antitumour [14,15] effects.…”

mentioning

confidence: 99%

Evaluation of DNA Damage in HepG2 Cells and Mutagenicity of Garcinielliptone FC, A Bioactive Benzophenone

Prado

Silva

Garcia

et al. 2017

Basic Clin Pharma Tox

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Garcinielliptone FC (GFC) is a polyprenylated benzophenone isolated from the hexanic extract of Platonia insignis seeds with potential pharmacological effects on the central nervous system. In a pre-clinical study, this compound showed anticonvulsant action, becoming a candidate to treat epilepsy disorders. However, genotoxicological aspects of GFC should be known to ensure its safe use. This study investigated the cytotoxic, genotoxic, and mutagenic effects of GFC. Cytotoxicity was evaluated using the colorimetric assay of MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) in human hepatoma cells (HepG2) (2-100 μg/mL) for 3, 6 and 24 hr. The genotoxic and mutagenic potentials were analysed using the alkaline version of the comet assay, the cytokinesis-block micronucleus cytome assay in HepG2 cells, and the Salmonella/microsome assay with the strains TA98, TA97a, TA100, TA102 and TA1535, with and without metabolic activation. GFC concentrations above 50 μg/mL were cytotoxic at all experimental times. Viability of HepG2 cells was higher than 70% after exposure to GFC 2-30 μg/mL for 3 hr in the MTT test. No GFC concentration was mutagenic or genotoxic in the Salmonella/microsome and comet assays. Nuclear division index decreased, indicating the cytotoxic effect of the compound, while micronucleus and nuclear bud frequencies rose after treatment with the highest GFC concentration tested (30 μg/mL). Nucleoplasmatic bridges were not observed. The results indicate that GFC is cytotoxic and mutagenic to mammalian cells, pointing to the need for further studies to clarify the toxicological potentials of this benzophenone before proceeding to clinical studies.

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Erratum: Bioactive acylphloroglucinols from Hypericum densiflorum

Cited by 3 publications

References 0 publications

Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Inhibition of Bacterial Growth and Biofilm Production by Constituents from Hypericum spp.

Identification of anti-inflammatory constituents in Hypericum perforatum and Hypericum gentianoides extracts using RAW 264.7 mouse macrophages

Evaluation of DNA Damage in HepG2 Cells and Mutagenicity of Garcinielliptone FC, A Bioactive Benzophenone

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