ERM, a PEA3 Subfamily of Ets Transcription Factors, Can Cooperate with c-Jun

Nakae, Kazuto; Nakajima, Kōichi; Inazawa, Johji; Kitaoka, Teruichirou; Hirano, Toshio

doi:10.1074/jbc.270.40.23795

Cited by 54 publications

(31 citation statements)

References 63 publications

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“…In contrast, c-Jun's coactivation function is less well understood. This c-Jun action appears to be limited to only a few transcriptional activators, including AR and the three ETS transcription factors ERM (Nakae et al, 1995), PU.1 (Behre et al, 1999), and ETV1 (C Cai and L Shemshedini, unpublished results).…”

Section: Discussionmentioning

confidence: 97%

c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation

Cai

et al. 2006

Oncogene

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Section: Discussionmentioning

confidence: 97%

c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation

Cai

et al. 2006

Oncogene

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“…Our ®nding that phosphorylation of these two serines is not required for c-Jun enhancement of ARinduced transactivation suggests a JNK-and Rasindependent mechanism by which c-Jun can modulate transcription. The prevalence of this potential mechanism is unknown, but it is interesting to note that c-Jun has an interaction with the Ets transcription factor, ERM (Nakae et al, 1995), that is similar to its interaction with AR. Future work will allow us to determine how similar these c-Jun interactions are and whether a common mechanism is involved.…”

Section: Discussionmentioning

confidence: 99%

Identification of domains of c-Jun mediating androgen receptor transactivation

et al. 1998

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“…Interaction with other proteins such as AP-1 family members (Nakae et al, 1995) or steroid hormone receptors (Schneikert et al, 1996) can modulate the activity of PEA3 subfamily members. Other potential interaction partners may exist which contribute to binding speci®city and/or relief of DNA binding inhibition.…”

Section: Dna Binding Properties Of Zebra®sh Pea3mentioning

confidence: 99%

Molecular characterization of the zebrafish PEA3 ETS-domain transcription factor

et al. 1998

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The PEA3 subfamily of ETS-domain proteins play important roles in regulating transcriptional activation and have been implicated in several tumorigenic processes. Here we describe the identi®cation of a further member of this family from zebra®sh which most likely represents a homologue of PEA3. A high degree of sequence conservation is observed in the ETS DNAbinding domain and acidic transcriptional activation domain. The DNA binding speci®city of zebra®sh PEA3 is virtually identical to that exhibited by mammalian family members and is autoregulated by cisacting inhibitory domains. Transcriptional activation by zebra®sh PEA3 is potentiated by the ERK MAP kinase and protein kinase A pathways. During embryogenesis, PEA3 is expressed in complex spatial and temporal patterns in both mesodermal somites and ectodermal tissues including the brain, dorsal spinal chord and neural crest. Our characterisation of zebra®sh PEA3 furthers our understanding of its molecular function and its expression pro®le suggests a novel role in cell patterning in the early vertebrate embryo.

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ERM, a PEA3 Subfamily of Ets Transcription Factors, Can Cooperate with c-Jun

Cited by 54 publications

References 63 publications

c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation

c-Jun enhancement of androgen receptor transactivation is associated with prostate cancer cell proliferation

Identification of domains of c-Jun mediating androgen receptor transactivation

Molecular characterization of the zebrafish PEA3 ETS-domain transcription factor

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