ERK5/HDAC5‐mediated, resveratrol‐, and pterostilbene‐induced expression of MnSOD in human endothelial cells

Abstract

Mol. Nutr. Food Res. 2016, 60, 266–277. DOI: Resveratrol and pterostilbene, present in fruits, red wine and some Chinese medicine herbs, activate MnSOD expression, and stimulate LKB1, AMPKα, ERK5 phosphorylation and HDAC5 and KLF2 expression in endothelial cells. Furthermore, two stilbenes promote KLF2 binding to human MnSOD promoter. These findings reveal a new mechanism underlying the anti‐aging effect two stilbenes exert on vascular endothelial cells.