Ericifolin: a novel antitumor compound from allspice that silences androgen receptor in prostate cancer

Shamaladevi, Nagarajarao; Lyn, Dominic; Shaaban, Khaled A.; Zhang, Lei; Villate, Susana; Rohr, Jürgen; Lokeshwar, Balakrishna L.

doi:10.1093/carcin/bgt123

Cited by 32 publications

(37 citation statements)

References 48 publications

(60 reference statements)

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“…Ericifolin was purified from an aqueous extract prepared from Allspice berries (AAE) that also inhibited PCa cell proliferation, colony formation and induced apoptosis and/or autophagy in PCa cells [77]. Importantly AAE inhibited AR promoter activity and mRNA stability leading to depletion of AR in AR-expressing cells [77]. …”

Section: Natural Products Against Pcamentioning

confidence: 99%

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

Kallifatidis

Hoy

Lokeshwar

2016

Seminars in Cancer Biology

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Prostate cancer (PCa), a hormonally-driven cancer, ranks first in incidence and second in cancer related mortality in men in most Western industrialized countries. Androgen and androgen receptor (AR) are the dominant modulators of PCa growth. Over the last two decades multiple advancements in screening, treatment, surveillance and palliative care of PCa have significantly increased quality of life and survival following diagnosis. However, over 20% of patients initially diagnosed with PCa still develop an aggressive and treatment-refractory disease. Prevention or treatment for hormone-refractory PCa using bioactive compounds from marine sponges, mushrooms, and edible plants either as single agents or as adjuvants to existing therapy, has not been clinically successful. Major advancements have been made in the identification, testing and modification of the existing molecular structures of natural products. Additionally, conjugation of these compounds to novel matrices has enhanced their bio-availability; a big step towards bringing natural products to clinical trials. Natural products derived from edible plants (nutraceuticals), and common folk-medicines might offer advantages over synthetic compounds due to their broader range of targets, as compared to mostly single target synthetic anticancer compounds; e.g. kinase inhibitors. The use of synthetic inhibitors or antibodies that target a single aberrant molecule in cancer cells might be in part responsible for emergence of treatment refractory cancers. Nutraceuticals that target AR signaling (epigallocatechin gallate [EGCG], curcumin, and 5α-reductase inhibitors), AR synthesis (ericifolin, capsaicin and others) or AR degradation (betulinic acid, di-indolyl diamine, sulphoraphane, silibinin and others) are prime candidates for use as adjuvant or mono-therapies. Nutraceuticals target multiple pathophysiological mechanisms involved during cancer development and progression and thus have potential to simultaneously inhibit both prostate cancer growth and metastatic progression (e.g., inhibition of angiogenesis, epithelial-mesenchymal transition (EMT) and proliferation). Given their multi-targeting properties along with relatively lower systemic toxicity, these compounds offer significant therapeutic advantages for prevention and treatment of PCa. This review emphasizes the potential application of some of the well-researched natural compounds that target AR for prevention and therapy of PCa.

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Section: Natural Products Against Pcamentioning

confidence: 99%

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

Kallifatidis

Hoy

Lokeshwar

2016

Seminars in Cancer Biology

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“…Hence, eugenol exhibits anti-breast cancer properties concentration both in vitro and in vivo, indicating that it could be used to consolidate the adjuvant treatment of breast cancer through targeting the E2F1/survivin pathway, especially for the less responsive triple-negative subtype of the disease [60]. Eugenol 5-O-β-(6'-galloylglucopyranoside) or ericifolin, showed antiproliferative, proapoptosis and anti-androgen receptor transcription activities, which suggested the potential use of aqueous allspice extract and ericifolin eugenol fraction against prostate cancer [61]. Cytotoxic concentrations of eugenol induced the reduction of ATP of oxidative stress and an increase in the polyamines and glycolytic metabolites, in normal oral cells and oral squamous cell carcinoma, suggests the induction of non-apoptotic cell death by eugenol [62].…”

Section: Anti-cancer Activitymentioning

confidence: 99%

Versatile and Synergistic Potential of Eugenol: A Review

Raja¹

2015

Pharm Anal Acta

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Eugenol (1-allyl-4-hydroxy-3-methoxybenzene) is the phenolic component of essential oil and the main constituent of Eugenia caryophyllata, Ocimmum gratissimum and several others medicinal plant. In view of its nonmutagenic and non-carcinogenic properties, eugenol is generally regarded as safe by the Food and Agricultural Organization of the United Nations. Eugenol has been recently shown to be effective for antimicrobials and treatment of different life threatening diseases including sepsis, leishmaniasis, and cancer. However overall, activity of eugenol is not discussed elsewhere. In this review, we discuss the current understanding of the mechanisms involved the antioxidant, antimicrobial, anticancer and anti-inflammatory potential of eugenol.

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“…Costa Ricans are known to use allspice to treat dyspepsia and diabetes and Guatemalans apply crushed Allspice berries to bruises, sore joints and for muscle ache [18]. A rich assortment of secondary metabolites can be obtained from the plant, which can be used for preserving the nutrients and protecting from bacterial and fungal infestation [19]. Some of these secondary metabolites include terpenoids, alkaloids, polyphenols, and glycosides [20].…”

Section: Introductionmentioning

confidence: 99%

<i>In Vitro</i> Analysis of the Antioxidant Effect of Allspice

Onwasigwe¹,

Verghese²,

Sunkara³

et al. 2017

FNS

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Antioxidants are free radical scavengers found in spices which may play a significant role in preventing cell death. Allspice is a dried unripe berry obtained from the Pimento dioica plant that may have antioxidant potential. The objective of this study was to determine the total phenolic, flavonoid content and antioxidant capacity of allspice using selected assays such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), Ferric Reducing Antioxidant Potential (FRAP) and Trolox Equivalent Antioxidant Capacity (TEAC), Nitric Oxide (NO) and Oxygen Reducing Antioxidant Capacity (ORAC). Total phenolic and flavonoid contents of allspice were determined using both water and methanol extraction. A comparison of antioxidant activity of water and methanol extracts of allspice was conducted using the different assays (DPPH, TEAC, NO, ORAC and FRAP). The total phenolic content (6.9%), NO scavenging (38.8%) and ORAC (35.1%) activity were higher in methanol compared to water extracts of allspice while flavonoids (57%), FRAP (11.2%), and TEAC (1.82%) were higher in water extracts compared to methanol extracts of allspice. The total phenolic and flavonoid content were higher in methanol extracts compared to water extracts of allspice. The IC50 (DPPH), FRAP and TEAC, NO scavenging and ORAC activity were higher in methanol extracts compared to water extracts of allspice. Total flavonoid content, FRAP and TEAC, NO scavenging and ORAC were significantly higher (p ≤ 0.5) in methanol extracts compared to water extracts of allspice. This shows that allspice has antioxidant potential and that the method of extraction can play a crucial role on the number of phytochemicals extracted from the plant. Utilization of allspice in food products may provide additional functional properties.

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Ericifolin: a novel antitumor compound from allspice that silences androgen receptor in prostate cancer

Cited by 32 publications

References 48 publications

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

Versatile and Synergistic Potential of Eugenol: A Review

<i>In Vitro</i> Analysis of the Antioxidant Effect of Allspice

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Ericifolin: a novel antitumor compound from allspice that silences androgen receptor in prostate cancer

Cited by 32 publications

References 48 publications

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer

Versatile and Synergistic Potential of Eugenol: A Review

&lt;i&gt;In Vitro&lt;/i&gt; Analysis of the Antioxidant Effect of Allspice

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<i>In Vitro</i> Analysis of the Antioxidant Effect of Allspice