Eradication of Helicobacter pylori as the only successful treatment in rosacea

Kolibasova, K.

doi:10.1001/archderm.132.11.1393

Cited by 28 publications

(13 citation statements)

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“…The speculation of Rebora and Kolibasova and their colleagues 10,13 on the relationship of H pylori and rosacea is not supported by our research. Curing H pylori infection does not clear rosacea within 60 days, and active treatment does not appear to have a more significant effect on the severity of rosacea than that of the use of placebo.…”

Section: Commentcontrasting

confidence: 93%

“…In Ukraine, Abrahamovych 12 in 1996 reported that of 160 patients with rosacea, 158 (98.8%) had endoscopic evidence of gastric disease, and 134 of those patients also had histological and urease breath test confirmation of H pylori infection. From Russia in 1996, Kolibasova et al 13 17 There is no therapy that permanently cures rosacea. This study was designed to test the effect of H pylori on clinically active rosacea and to see if the cure of H pylori infection would bring a corresponding clearing of rosacea.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Treatment of Helicobacter pylori Infection on Rosacea

Bamford¹,

Tilden²,

Blankush³

et al. 1999

Arch Dermatol

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To evaluate the clearing and intensity of symptoms of rosacea 60 days after the treatment of Helicobacter pylori infection.Design: Randomized, double-blind, placebo-controlled clinical trial. Setting:The dermatology section of a large multispecialty clinic in the North Central United States.Participants: Men and women older than 25 years with active signs of rosacea who tested positive for H pylori with both the rapid whole blood test and the urea breath test.Intervention: Treatment of H pylori infection with 14day therapy using clarithromycin, 500 mg orally 3 times a day, and omeprazole, 40 mg orally once a day. Main Outcome Variables:The extent and intensity of rosacea as measured by the number of papules and pus-tules and the extent and intensity of erythema and telangiectasia.Results: Three hundred twenty patients presented with rosacea. For 50 patients, the results of a urea breath test were positive for H pylori, and 44 patients were enrolled in the study. Rosacea abated in almost all patients, but none were cured. Notably, lessening of rosacea for patients treated for H pylori was not significantly better than for the control cohort.

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Section: Commentcontrasting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Effect of Treatment of Helicobacter pylori Infection on Rosacea

Bamford¹,

Tilden²,

Blankush³

et al. 1999

Arch Dermatol

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“…Incidentally, anemia, hemoptysis and vertigo have been reported [71,72] . The association of H. pylori with extradigestive diseases, such as functional vascular diseases and skin and endocrine autoimmune diseases, has been described [73][74][75][76] . An interesting relationship between seropositivity to H. pylori, serum glucose and non-insulin dependent diabetes mellitus is worthy of further attention.…”

Section: Symptomsmentioning

confidence: 99%

“…Many patients with autoimmune thyroid diseases a re infected with type I cytotoxic cagA-positive strains [75] . Rosacea and recurrent urticaria may also be associated with H. pylori infection [76] . Alopecia areata is related to atrophic gastritis and pernicious anemia, and thus with H. pylori [74] .…”

Section: Symptomsmentioning

confidence: 99%

Helicobacter pyloriinfection

Vandenplas¹

2000

WJG

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“…The role of H. pylori infection in the etiopathogenesis of rosacea and chronic urticaria is still controversial. Several studies have suggested a possible relationship between H. pylori and rosacea [7,8,[24][25][26][27] and chronic urticaria [28][29][30], although some evidences against this association have been reported [31][32][33][34][35]. The aim of the present study was to investigate the relationship between H. pylori infection and two skin disorders (rosacea and chronic urticaria) by means of immunoproteomic methodologies.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria

Mini¹,

Figura²,

D’Ambrosio³

et al. 2005

Proteomics

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Rosacea and chronic urticaria are two common skin disorders existing in idiopathic forms. A role of Helicobacter pylori bacterium infection in the aetiopathogenesis of rosacea or chronic urticaria has been suggested although still controversial. The aim of the present study was to establish a relationship between H. pylori infection and rosacea chronic urticaria by means of an immunoproteomic investigation. We analyzed immunoglobulin A (IgA)-, IgG-, and IgE-mediated immune-responses against H. pylori antigens and we identified some bacterial immunoresponsive proteins. A general IgA- and IgE-mediated immune response against antioxidative bacterial proteins was observed. A correlation between the bacterial occurrence and skin diseases pathogenesis is discussed.

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Eradication of Helicobacter pylori as the only successful treatment in rosacea

Cited by 28 publications

References 0 publications

Effect of Treatment of Helicobacter pylori Infection on Rosacea

Effect of Treatment of Helicobacter pylori Infection on Rosacea

Helicobacter pyloriinfection

Helicobacter pylori immunoproteomes in case reports of rosacea and chronic urticaria

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