Eradication of Aujeszky's disease from New Zealand pig herds 1976–1997

Pannett, G. R.; Motha, M.X.J.; MacDiarmid, S.C.

doi:10.1136/vr.144.14.365

Cited by 12 publications

(9 citation statements)

References 13 publications

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“…Increasing international trade restrictions resulting from the new EU legislation, currency losses and the heterogeneous and difficult epidemiological situation inside the country prompted the establishment of a national control and eradication programme in Germany, similar to pioneering programmes in Italy (Lodetti and Amadori, 1992), the USA (Annelli, 1993;Bech-Nielsen et al, 1995), the Netherlands (Stegeman, 1997), New Zealand (Pannett et al, 1999) and Sweden (Andersson et al, 1997). At the beginning of the past decade, the German national AD eradication programme was mainly adapted to the epidemiological situation in the Western parts of the country.…”

Section: The German Aujeszky's Disease Eradication Programmementioning

confidence: 99%

Eradication of Aujeszky's Disease in Germany

Müller¹,

Bätza

Schlüter³

et al. 2003

Journal of Veterinary Medicine, Series B

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Aujeszky's disease (AD) manifested itself in both German states in 1960. Owing to the historical development, in the subsequent two decades, the development of the disease and of its control in the Western and Eastern parts of Germany went different ways. This article describes differences and particularities in the development of AD in Germany leading to the establishment of a national AD eradication programme after re-unification of the two German states at the beginning of the last decade. The basic principles of the German AD eradication programme are described, and the results of 10 years of efforts to control the disease are presented and discussed. Without any doubt, as in other European countries, implementation of the national eradication programme resulted in a considerable progress in the eradication of AD. Since the eradication programme has been established in 1989, particularly in West Germany, the number of AD outbreaks has decreased steadily from about 2000 cases in 1987 to 0 cases recorded in 2001. Recently, Germany has been declared as officially AD-free by the European Commission.

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Section: The German Aujeszky's Disease Eradication Programmementioning

confidence: 99%

Eradication of Aujeszky's Disease in Germany

Müller¹,

Bätza

Schlüter³

et al. 2003

Journal of Veterinary Medicine, Series B

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“…The demographics, patterns of work and information needs of veterinarians in New Zealand were examined in detail Morris 1988, 1989) and vaccine effi cacy (Motha et al 1987) and sero-prevalence studies (MacDiarmid 1990) set the stage for what proved to be a successful industry-funded programme for eradication of Aujesky's disease from pig herds (Pannett et al 1999).…”

Section: The 1980smentioning

confidence: 99%

Veterinary epidemiology in New Zealand: a 50-year perspective

Jackson

2002

New Zealand Veterinary Journal

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Extract The science of epidemiology is still developing although some of its principal tenets, such as identification of risk factors through comparisons of rates of disease occurrence among population sub-groups of individuals, have been used for centuries. The past 50 years has seen a particularly rapid period of growth of the discipline that has become almost exponential, especially since microcomputers and powerful analytical programs became widely available in the 1980s. The most outstanding advance has arguably been the development of causal criteria that arose from the fierce debate about links between smoking and lung cancer. The philosophical concepts of associations between cause and effect that are embodied in causal criteria now underpin epidemiological practice for scientific evaluation of evidence.

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“…Currently, the disease control is carried out mainly through vaccination using attenuated gene-deletion vaccines along with differential diagnosis to differentiate vaccinated from infected animals (Muller et al, 2011;Freuling et al, 2017). Since the implementation of this strategy in 1980s, PRV has been successfully eradicated from domestic pigs of many countries, including the United States, most of Europe and New Zealand (Pannett et al, 1999;An et al, 2013;Ketusing et al, 2014;Freuling et al, 2017). For the Chinese swine industry, has been widely used since early 1990s (An et al, 2013;Sun et al, 2016); it was imported from Hungary in 1979 that contains a complete deletion of the region coding for glycoprotein E (gE) and US9 and partial deletion within the gI and US2 coding regions (Bartha, 1961;Yuan et al, 1983;Lomniczi et al, 1984).…”

Section: Introductionmentioning

confidence: 99%

Glycoproteins C and D of PRV Strain HB1201 Contribute Individually to the Escape From Bartha-K61 Vaccine-Induced Immunity

et al. 2020

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The newly emerged pseudorabies virus (PRV) novel variants can escape from the immunity induced by the classical vaccine Bartha-K61. Here we investigated the underlying mechanisms by constructing chimeric mutants between epidemic strain HB1201 and the Bartha-K61 vaccine. Our analyses focused on three viral envelope glycoproteins, namely gB, gC, and gD, as they exhibit remarkable genetic variations and are also involved in induction of protective immunity. The corresponding genes were swapped reciprocally either individually or in combination by using CRISPR/Cas9 technology and homologous recombination. The rescued chimeric viruses exhibited differential sensitivity to neutralizing antibodies in vitro, and gC was found to be the major contributor to inefficient neutralization against HB1201 by anti-Bartha-K61 serum. When tested in the 4-week-piglet model, substitution with HB1201 gC enabled Bartha-K61 to induce a protective immunity against HB1201 at a high challenge dose of 10 7 TCID 50. Interestingly, despite a relatively lower cross-neutralization ability, the gD exchange also enabled Bartha-K61 to protect piglets from lethal challenge. In both cases, clinical signs and microscopic lesions were eased, and so was the viral tissue load with the exception of brain. A better protection could be achieved when both gC and gD were swapped in terms of reducing viral load in brain and virus-induced microscopic lesions. Thus, our studies not only revealed individual roles of gC and gD variations in the immune escape and also suggested a synergistic effect of both proteins on induction of protective immunity. These findings have important implications in novel vaccine development for PRV control in China.

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Eradication of Aujeszky's disease from New Zealand pig herds 1976–1997

Cited by 12 publications

References 13 publications

Eradication of Aujeszky's Disease in Germany

Eradication of Aujeszky's Disease in Germany

Veterinary epidemiology in New Zealand: a 50-year perspective

Glycoproteins C and D of PRV Strain HB1201 Contribute Individually to the Escape From Bartha-K61 Vaccine-Induced Immunity

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