Er en belastet barndom knyttet til kortere telomerer?

Næss, Ane Brandtzæg; Kirkengen, Anna Luise

doi:10.4045/tidsskr.14.1194

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…Several different lines of research have found links between adverse life experiences in the early years of life and adult telomere length (11–13). These studies are difficult to interpret given that adversities tend to co-occur.…”

Section: Discussionmentioning

confidence: 99%

“…For example, perceived neighborhood quality (4–6), anxiety (7), exposure to intimate partner violence (8, 9), and being the primary caregiver of a child with a chronic condition (10) are all inversely correlated with telomere length, as typically measured during adulthood. Associations between telomere length and adverse early life experiences have also been observed (11–13). Adults reporting physical or emotional neglect during childhood had shorter telomeres than their counterparts who did not report any childhood maltreatment (14).…”

Section: Introductionmentioning

confidence: 95%

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Early-Life Experiences and Telomere Length in Adult Rhesus Monkeys: An Exploratory Study

et al. 2016

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Objective Child rearing environments have been associated with morbidity in adult rhesus monkeys. We examine whether such links are also seen with leukocyte telomere length. Methods To determine telomere length in leukocytes, blood was collected from 11 adult females aged seven to ten years who had been exposed to different rearing environments between birth and seven months. Four had been reared with their mothers in typical social groups comprised of other females, their offspring, and 1–2 adult males. The other seven had been reared in either small groups of peers or in individual cages with extensive peer interaction daily. After seven months, all shared a common environment. Results Telomere lengths were longer for those adults who had been reared with their mothers in social groups (median = 16.0 kb, interquartile range = 16.5–15.4) than for those who were reared without their mothers (median = 14.0 kb, interquartile range = 14.3–12.7; 2.2 kb/telomere difference, p<0.027). Conclusions This observation adds to emerging knowledge about early adverse child rearing conditions and their potential for influencing later morbidity. As newborns were randomly assigned to the mother or other rearing conditions, the findings are not confounded by other conditions that co-occur with adverse child rearing environments in humans (e.g., prenatal stress, nutrition and health as well as postnatal nutrition and negative life experiences over and above rearing conditions).

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Section: Discussionmentioning

confidence: 99%