Equator ring efficacy in maintaining capsular bag integrity and transparency after cataract removal in monkey eyes

Abstract

l Background: The purpose of the study was to evaluate the efficacy of the equator ring in maintaining capsular bag integrity at the equator and transparency of the posterior capsule after cataract surgery, using cynomolgus monkeys. l Methods: After lens removal using an infusion-aspiration method, a flexible silicone ring with a groove on its inner surface was inserted in the bag through a window made by continuous circular capsulorhexis in six eyes. Of these, four monkey eyes underwent posterior chamber intraocular lens (IOL) implantation and two monkey eyes did not receive IOLs. Lensectomy without ring insertion was performed as a control in the six fellow eyes. Of these, four eyes received an IOL and two did not. The eyes were followed for an average of 5.9 1.1 months before enucleation. The effects were evaluated by stereo and light microscopy. l Results: The ring effectively maintained the circular contour of the capsular bag (ratio of the short and long axes, 0.97 0.01) and posterior capsule transparency (P = 0.017). l Conclusions: This study demonstrated that the equator ring is a promising device for maintaining capsular bag integrity and minimizing posterior capsule opacification after cataract surgery.

Preventing Posterior Capsular Opacification With an Endocapsular Equator Ring in a Young Human Eye

“…We have accumulated acceptable results with the current ring in rabbit and monkey eyes. 10,11 The current results proved the same efficacy in a human eye for the first time. The ring can prevent PCO in an area wider than the IOL optic.…”

Preventing Posterior Capsular Opacification With an Endocapsular Equator Ring in a Young Human Eye

“…We have accumulated acceptable results with the current ring in rabbit and monkey eyes. 10,11 The current results proved the same efficacy in a human eye for the first time. The ring can prevent PCO in an area wider than the IOL optic.…”

An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opacification Using a Human Capsular Bag Model

“…[7][8][9] Similar results in rabbit eyes have been shown with a novel disc design of IOL, which keeps the bag open. 10 This animal work has been corroborated by clinical observations with the Synchrony dual optic IOL (Abott Medical Optics, Santa Ana, CA, USA), which was developed as an accommodating IOL and consists of two linked IOLs implanted in the capsular bag which, by coincidence, keep the capsule open; an impressive observation has been that these eyes have extremely low PCO rates.…”

Further Enhancement of Intraocular Open-Capsule Devices for Prevention of Posterior Capsule Opacification

“…Even with the improved skills and new technologies, PCO still is the most common complication following an uneventful cataract surgery. Great efforts have been expended to reduce the rate of PCO, including pharmacologic measures, 21 , 22 surgical techniques, 31 devices, 23 – 28 preventive laser treatment, 32 , 33 IOL materials, 13 , 18 , 31 , 34 , 35 and IOL designs. 12 – 19 , 36 Adding a sharp posterior edge to IOLs has reduced significantly the PCO rates and the subsequent need for Nd:YAG laser capsulotomy.…”

Preventing Posterior Capsular Opacification With an Endocapsular Equator Ring in a Young Human Eye

“…We have accumulated acceptable results with the current ring in rabbit and monkey eyes. 10,11 The current results proved the same efficacy in a human eye for the first time. The ring can prevent PCO in an area wider than the IOL optic.…”

An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opacification Using a Human Capsular Bag Model

“…[7][8][9] Similar results in rabbit eyes have been shown with a novel disc design of IOL, which keeps the bag open. 10 This animal work has been corroborated by clinical observations with the Synchrony dual optic IOL (Abott Medical Optics, Santa Ana, CA, USA), which was developed as an accommodating IOL and consists of two linked IOLs implanted in the capsular bag which, by coincidence, keep the capsule open; an impressive observation has been that these eyes have extremely low PCO rates.…”

Further Enhancement of Intraocular Open-Capsule Devices for Prevention of Posterior Capsule Opacification

“…Even with the improved skills and new technologies, PCO still is the most common complication following an uneventful cataract surgery. Great efforts have been expended to reduce the rate of PCO, including pharmacologic measures, 21 , 22 surgical techniques, 31 devices, 23 – 28 preventive laser treatment, 32 , 33 IOL materials, 13 , 18 , 31 , 34 , 35 and IOL designs. 12 – 19 , 36 Adding a sharp posterior edge to IOLs has reduced significantly the PCO rates and the subsequent need for Nd:YAG laser capsulotomy.…”

Preventing Posterior Capsular Opacification With an Endocapsular Equator Ring in a Young Human Eye

“…We have accumulated acceptable results with the current ring in rabbit and monkey eyes. 10,11 The current results proved the same efficacy in a human eye for the first time. The ring can prevent PCO in an area wider than the IOL optic.…”

An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opacification Using a Human Capsular Bag Model

“…[7][8][9] Similar results in rabbit eyes have been shown with a novel disc design of IOL, which keeps the bag open. 10 This animal work has been corroborated by clinical observations with the Synchrony dual optic IOL (Abott Medical Optics, Santa Ana, CA, USA), which was developed as an accommodating IOL and consists of two linked IOLs implanted in the capsular bag which, by coincidence, keep the capsule open; an impressive observation has been that these eyes have extremely low PCO rates.…”

Further Enhancement of Intraocular Open-Capsule Devices for Prevention of Posterior Capsule Opacification

“…Even with the improved skills and new technologies, PCO still is the most common complication following an uneventful cataract surgery. Great efforts have been expended to reduce the rate of PCO, including pharmacologic measures, 21 , 22 surgical techniques, 31 devices, 23 – 28 preventive laser treatment, 32 , 33 IOL materials, 13 , 18 , 31 , 34 , 35 and IOL designs. 12 – 19 , 36 Adding a sharp posterior edge to IOLs has reduced significantly the PCO rates and the subsequent need for Nd:YAG laser capsulotomy.…”