Epstein-Barr virus-related persistent erythema multiforme in chronic fatigue syndrome

Drago, Francesca

doi:10.1001/archderm.128.2.217

Cited by 14 publications

(15 citation statements)

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“…10 Annular cutaneous lesions have also been reported in patients with chronic EBV infection. [11][12][13] To our best knowledge, our patient might represent the third reported case of annular lesions in EBV-related IM. Cefotaxime prescribed by previous medical practitioners caring for the patient could have been a precipitating factor in the development of such eruption.…”

Section: Case Reportmentioning

confidence: 59%

Erythema multiforme-like lesions in the course of infectious mononucleosis

Zawar¹,

Chuh²,

Sankalecha³

2009

J Dermatol Case Rep

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Background: The rash in infectious mononucleosis is usually diffusely macular.Main observations: A 15-year-old boy presented to us with high grade fever, sore throat, malaise, body aches, and polyarthralgia. He developed annular, erythematous, and non-scaly eruptions on chest and right arm. Blanching erythema was noted on his trunk. He had bilateral tender cervical lymph nodes, severe pharyngeal congestion, petechiae on soft palate, uvular edema, infraorbital edema, and marginal tender hepatomegaly. Investigations revealed lymphocytosis and activated atypical lymphocytes in the peripheral smear, and positive monospot test. The boy subsequently recovered in one week with total disappearance of his rash. Epstein-Barr virus-related infectious mononucleosis was considered the most likely diagnosis for our patient.

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Section: Case Reportmentioning

confidence: 59%

Erythema multiforme-like lesions in the course of infectious mononucleosis

Zawar¹,

Chuh²,

Sankalecha³

2009

J Dermatol Case Rep

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“…Although the precise pathogenesis of erythema multiforme is unknown, herpes simplex infection is strongly involved in the pathogenesis [15]. However, many other factors such as mycoplasma [16], Epstein-Barr virus [17], adenovirus infection [18]or some drugs can be important trigger factors [15]. We show here rare cases of erythema multiforme induced by CMV infection.…”

Section: Discussionmentioning

confidence: 82%

Erythema multiforme Associated with Cytomegalovirus Infection in Nonimmunosuppressed Patients

2001

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Background: It is widely known that cytomegalovirus (CMV) primarily brings about subclinical and asymptomatic infection in the early stages of life and can cause various dermatological and systemic disorders under immunosuppressed conditions. Nonimmunosuppressed individuals very rarely present with cutaneous CMV involvement. Objective: In the present study, we described the clinical characteristics of 5 nonimmunosuppressed adult patients with positive IgM antibody to CMV. Methods: The systemic symptoms and dermatological features of these 5 patients were described. Laboratory examinations including blood cell counts, liver and renal functions were performed. IgG and IgM antibodies to CMV were also examined at the first consultation and 2–3 months after the skin eruption. Polymerase chain reaction for CMV DNA was performed in the skin samples of the patients. Results: All 5 patients had fever and complained of a sore throat. Multiple exudative erythema and target lesions with itching were observed mainly on the extremities. These symptoms and eruptions disappeared within 1 week after the onset and IgM antibody titers significantly decreased after 2–3 months. IgG antibody to CMV was already positive in 3 cases but was negative in 2 cases at the initial consultation. Conclusion: We propose that CMV infection may cause erythema multiforme by primary, recurrent infections or reactivation of CMV even in nonimmunosuppressed adults.

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“…Bu gruplar içinde en sık viral nedenlere bağlı gelişen PEM'li olgular bildirilmiş olup, etken olarak en sık HSV ve EBV saptanmıştır. 4,5 Tabloya eşlik eden malinite olarak ise renal karsinom ve mide karsinomunun varlığı bildirilmiştir. 3 Üç olgunun sunulduğu bir yayında iki olguda etyolojide neden tespit edilemezken, bir olguda ise İnfluenza B virüs'üne karşı oluşan antikor titresinde artış tespit edilmiştir 4 .…”

Section: Discussionunclassified

“…1,2 Klinik olarak klasik, rekür-ren ve persistan tip olmak üzere 3 grupta sınıflandırılmakta-dır. [3][4][5][6] Persistan eritema multiforme (PEM), eritema multiformenin tipik ve atipik deri ve/veya mukoza lezyonlarının sürek-li tekrarladığı, nadir görülen ve daha az bilinen bir klinik şekli-dir 3,4,6 . Hastalığın klinik seyri ise tanıda önemlidir 4 .…”

Section: Gi Riflunclassified

Persistan Eritema Multiforme

Bayramgürler¹,

Aktürk²,

Yıldız³

et al. 2011

Turkderm

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ÖzetEritema multiforme (EM) özellikle akral bölgelere yerleşim gösteren, tipik olarak hedef benzeri eritemli makül ve papüllerle karakterize mukokutanöz bir deri hastalığıdır. Klinik olarak klasik, rekürren ve persistan tip olarak 3 alt grupta sınıflandırılmaktadır. Persistan eritema multiforme (PEM), sürekli görülen tipik EM lezyonları ve eritematöz papül-plaklar, hedef tarzı lezyonlar, büller ve nekrotik lezyonlar gibi atipik deri ve mukoza lezyonları ile karakterize EM'nin nadir bir varyantıdır. Burada persistan eritema multiforme tanısı konulan ve asiklovir tedavisi ile düzelen 30 yaşında bir kadın hasta sunuyoruz. Ek olarak, olgumuz Türkiye'de rapor edilen PEM'li ilk olgudur. (Türk derm 2011; 45: 210-12) Anah tar Ke li me ler: Eritema multiforme, persistan, asiklovir Sum maryErythema multiforme (EM) is a mucocutaneous disease characterized by the typical target-like erythematous papules and plaques especially localized on the acral regions. It is classified clinically into three subgroups as classical, recurrent and persistent type. Persistent EM (PEM) is a rare variant of EM characterized by the continuous appearance of typical EM lesions and atypical cutaneous or mucosal lesions such as erythematous papules-plaques, targetoid lesions, blistering and necrotic lesions. PEM can be induced by viruses or some malignant and inflammatory underlying diseases although there are some idiopathic cases. Here, we report a 30-year-old woman who was diagnosed as PEM and responded well to treatment with acyclovir. In addition, our case is the first reported case with PEM in Turkey. (Turk derm 2011; 45: 210-12

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Epstein-Barr virus-related persistent erythema multiforme in chronic fatigue syndrome

Cited by 14 publications

References 0 publications

Erythema multiforme-like lesions in the course of infectious mononucleosis

Erythema multiforme-like lesions in the course of infectious mononucleosis

Erythema multiforme Associated with Cytomegalovirus Infection in Nonimmunosuppressed Patients

Persistan Eritema Multiforme

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