1997
DOI: 10.1001/archderm.133.7.867
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Epstein-Barr virus-associated lymphoproliferative disease during methotrexate therapy for psoriasis

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Cited by 26 publications
(24 citation statements)
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“…9 Furthermore, treatment with immunosuppressive medications used to treat psoriasis may be an independent risk factor for developing lymphoproliferative malignancies 10 ; or it may be that having psoriasis and being exposed to immunomodulating medications results in an increased risk of developing lymphomas. There have been several case reports of patients with or without psoriasis who were treated with methotrexate [11][12][13][14] or cyclosporine [15][16][17] and later diagnosed with lymphomas. 18,19 There is also an increasing number of reports of lymphomas developing in patients treated with tumor necrosis factor ␣ inhibitors, which suggests that other treatments may also be associated with inducing lymphomas.…”
Section: Discussionmentioning
confidence: 99%
“…9 Furthermore, treatment with immunosuppressive medications used to treat psoriasis may be an independent risk factor for developing lymphoproliferative malignancies 10 ; or it may be that having psoriasis and being exposed to immunomodulating medications results in an increased risk of developing lymphomas. There have been several case reports of patients with or without psoriasis who were treated with methotrexate [11][12][13][14] or cyclosporine [15][16][17] and later diagnosed with lymphomas. 18,19 There is also an increasing number of reports of lymphomas developing in patients treated with tumor necrosis factor ␣ inhibitors, which suggests that other treatments may also be associated with inducing lymphomas.…”
Section: Discussionmentioning
confidence: 99%
“…[39][40][41] Suzuki et al 42 reported a case of pulmonary lymphoma positive for Epstein-Barr viral RNA, which developed in a patient with severe psoriasis who had been taking MTX for 15 years. This report lends evidence to the theory that the absence of adequate immunoregulation induced by MTX allows for an uninhibited EBV-induced polyclonal proliferation of B cells and subsequent B-cell lymphoma.…”
Section: Methotrexatementioning
confidence: 99%
“…Patients treated with MTX have increased susceptibility to EB virusepositive lymphomas. [8][9][10]12,[15][16][17] The mechanisms of an increased risk of EB virusepositive lymphomas are uncertain, but the immunosuppressive effect of MTX and/or a direct effect of MTX on EB virus reactivation may be important factors. 18 An analysis of MTX-related LPD (MTX-LPD) in patients with RA revealed that approximately half of the cases were nodal, and the histologic features included B-cell LPD (diffuse large B-cell lymphoma, follicular lymphoma, lymphoplasmacytic, diffuse polymorphic, and Hodgkin lymphoma [HL]-like LPD), T-cell LPD, natural killer/T-cell LPD, and HL.…”
Section: Discussionmentioning
confidence: 99%
“…3,4 Patients who receive long-term methotrexate (MTX) therapy for inflammatory diseases, such as rheumatoid arthritis (RA), dermatomyositis, and psoriasis, have an increased risk of developing LPD. [5][6][7][8][9][10][11][12] Here, we describe a patient with RA who was treated with MTX and developed extensive vascular involvement with atypical lymphoid cells in the skin.…”
mentioning
confidence: 99%