Epithelium: sticking it out, together

Stevens, Troy

doi:10.1152/ajplung.00034.2008

Cited by 1 publication

(1 citation statement)

References 10 publications

(12 reference statements)

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“…Irrespective of the deleterious effect of the virus on the immune system and the underlying diseases, the widespread loss of intercellular cohesion between adjacent bronchiolar and alveolar epithelial cells associated with the measles infection must have been at least a factor that contributed to death. The physiological state in which adjacent respiratory epithelial cells are tethered is E-cadherin dependent, and disruption of this bond leads to barrier malfunction ( 40 ). However, E-cadherin is responsible not only for epithelial cell binding but also for the bond between DCs and epithelial cells ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

Macrophages and Dendritic Cells Are the Predominant Cells Infected in Measles in Humans

Allen¹,

McQuaid²,

Peñalva³

et al. 2018

mSphere

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We have brought together a unique collection of 23 human cases of measles infection and studied the types of cells that are infected. This work has not been done with modern technologies such as double labeling with antibodies and confocal microscopy in human cases primarily due to the fact that it is difficult to obtain the material because, fortunately, measles is fatal in only a very small fraction of infected patients. During the past decades, the receptors for measles virus have been elucidated and monkey models have been developed. We found that, in most cases, independently of whether the tissues were obtained early or later in the infection, the primary cell types that were infected were those of the immune system such as lymphocytes, macrophages, and dendritic cells. A very small number of epithelial cells were also found to be infected.

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Section: Discussionmentioning

confidence: 99%