Epithelioid Sarcoma in the Cervical Spine: A Case Report

Lee, Chungnam; Choe, Wonyoung; Kim, Nara

doi:10.14245/kjs.2015.12.3.165

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…[ 16 ] In Lee's report, the patient with ES in the cervical spine underwent multiple surgeries and died from respiratory failure due to local invasion in the trachea. [ 17 ] In the current case, the patient experienced 2 recurrences after the surgery.…”

Section: Discussionmentioning

confidence: 72%

Long period of relative quiescence in distal-type epithelioid sarcoma of the forearm with recurrence after surgery

Zhang

Jiang²,

Shi³

et al. 2018

Medicine

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Background:Epithelioid sarcoma (ES) is a rare malignant mesenchymal tumor that only accounts for 0.6% to 1.0% of all cases of sarcomas. ES with a relative quiescent state of more than 10 years is extremely rare.Here, we present a rare case of ES in the forearm of a 17-year-old girl. The patient had a congenital mass in her forearm that measured approximately 1cm; it grew rapidly starting 5 years ago. The mass was not treated until last year when she underwent the first surgery. The mass was located in the middle and lower part of the left forearm and involved the dorsal muscle group, intermuscular space, and subcutaneous tissues without clear boundaries.The patient underwent surgery, and the tumor recurred twice within 1 year postoperatively.Methods:The tumor samples were examined via hematoxylin-eosin (HE) and immunohistochemistry staining.Results:Histopathologically, the tumor comprised large polygonal epithelioid cells with abundant eosinophilic cytoplasm arranged in cell nests. Central necrosis and focal myxoid change could be seen in the tumor tissues. Immunostaining showed that the tumor cells were positive for CD34, CK, EMA, and vimentin but negative for CD31, S-100, and INI-1.Conclusion:Based on these findings, the tumor was diagnosed as ES of distal form. Distal-type ES could have a long period of relative quiescence, after which it could grow rapidly and relapse multiple times over a short duration.

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Section: Discussionmentioning

confidence: 72%

Long period of relative quiescence in distal-type epithelioid sarcoma of the forearm with recurrence after surgery

Zhang

Jiang²,

Shi³

et al. 2018

Medicine

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“…A total of 13 studies were included in this study [10][11][12][13][14][15][16][17][18][19][20][21][22], including 5 studies from the United States and 1 study each from Japan, Portugal, South Korea, Italy, Thailand, Germany, Switzerland, and Canada. The studies were published from 2006 to 2021.…”

Section: Study Inclusionmentioning

confidence: 99%

Systematic Review of Published Cases of Primary Epithelioid Sarcoma of the Spine

et al. 2022

Med Sci Monit

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Background:Epithelioid sarcoma is rare, represents less than 1% of all sarcomas, usually occurs in the extremities, and rarely presents as a primary sarcoma of the spine. Publications are usually single reports or case series. We aimed to undertake a systematic review of publications of cases of primary epithelioid sarcoma of the spine to evaluate clinical presentation, diagnosis, management, and patient outcomes. Material/Methods:We searched studies on spinal epithelioid sarcoma in the PubMed database. Only studies with secondary epithelioid sarcoma or without effective data for analysis were excluded. Cases in which epithelioid sarcoma first invaded other sites and then affected the spine were also excluded. Results:Twenty-three patients from 13 studies were included in the study, aged between 14 and 65 years, and the sex ratio of female to male was 1: 2.29. The survival time was 18.7±13.8 months. The survival time of males was longer than that of females (22.9±14.4 vs 9.0±4.6, P=0.027). The onset age was linearly correlated with the size of the lesion (size=-0.161*age+11.841).The lesions located in lumbar vertebra had the worst prognosis.Postoperative radiotherapy had a statistically significant effect on survival time (P=0.040). Conclusions:This systematic review identified 23 published cases of primary epithelioid sarcoma of the spine. Pain was the main presenting symptom, and tumor size increased with patient age. Female sex and primary location in the lumbar spine were associated with poor survival. Although surgery was the first-line treatment, postoperative radiotherapy and chemotherapy may improve clinical outcomes.

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“…Distal type has the same anatomical localisation but on distal limbs. Rare cases have been reported in the pelvis, vulva, penis, and spine [1][2][3][4][5] . This case report describes ES in femoral nerve and it is the first case of ES at this anatomical location on the basis of avaible literature data.…”

Section: Introductionmentioning

confidence: 99%

Epithelioid sarcoma of femoral nerve: A case report

2018

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Introduction. Epithelioid sarcoma is a slow-growing malignant soft tissue tumor and occurs approximately in 1% of all soft tissue malignant tumors. This case report describes epithelioid sarcoma in femoral nerve and as we know it is the first described case of epithelioid sarcoma at this anatomical localisation. Case report. A 44-years-old female patient presented with strong pain in her left leg. On magnetic resonance imaging (MRI), tumor was presented as a node 8 cm in the diameter at left femoral nerve between ileopsoas and iliacus muscle, without infiltration of muscle fascia and tendons. Four enlarged lymph nodes described in left iliac fosa, were suspected on secondary tumor deposits. We preformed radical surgical excision of the tumor and femoral nerve transection with local lymp hnode disection. Histopa-thological analysis revealed epithelioid sarcoma, and tumor stained highly positive for anti-pan cytokeratin antibody (AE1/AE3), vimentin, cancer antigen 125 (CA125), anticytokeratin antibody (MNF116), hematopoietic progenitor cell antigen (CD34) and epithelial membrane antigen (EMA) markers. After the operation patient recived radiotherapy without chemotherapy. Six months postoperatively, there was no evidence of local relapses or distant metastases. Conclusion. Initial wide surgical resection and adjuvant radiotherapy is beneficial in treatment of epitheloid sarcoma.

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Epithelioid Sarcoma in the Cervical Spine: A Case Report

Cited by 5 publications

References 17 publications

Long period of relative quiescence in distal-type epithelioid sarcoma of the forearm with recurrence after surgery

Long period of relative quiescence in distal-type epithelioid sarcoma of the forearm with recurrence after surgery

Systematic Review of Published Cases of Primary Epithelioid Sarcoma of the Spine

Epithelioid sarcoma of femoral nerve: A case report

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