Epithelial and mixed hepatoblastoma in the adult

Altmann, Heidi

doi:10.1016/s0344-0338(11)81151-9

Cited by 41 publications

(3 citation statements)

References 15 publications

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“…This contrasts with most cases of adult hepatoblastoma reported in the literature, in which the tumour usually evolved slowly and was sometimes discovered incidentally at surgery or autopsy 45 7 In addition, some cases of adult hepatoblastoma have been successfully treated by surgery, leading to complete remission, without any evidence of recurrence after prolonged follow up 5. It is likely that the concomitant immunosuppressive treatment administered to our patient was largely responsible for the very rapid evolution of the tumour.…”

Section: Discussioncontrasting

confidence: 73%

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Recurrence of hepatocellular carcinoma as a mixed hepatoblastoma after liver transplantation

Dumortier

Bizollon

Chevallier

et al. 1999

Gut

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Section: Discussioncontrasting

confidence: 73%

“…The occurrence of blastomatous lesions associated with otherwise typical hepatocarcinoma has been previously described 5. In the present case, this possibility has been excluded by careful examination of the resected liver.…”

Section: Discussionsupporting

confidence: 54%

Recurrence of hepatocellular carcinoma as a mixed hepatoblastoma after liver transplantation

Dumortier

Bizollon

Chevallier

et al. 1999

Gut

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“…An extensive English literature search revealed only 36 reports including 40 patients with adult hepatoblastoma dating back to 1958 [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40]. Before Carter [9] initially reported a patient with adult hepatoblastoma in the English literature, hepatic embryonic mixed tumor, mixed tumor and embryonic tumor had been reported as hepatoblastoma [5,6,7,8,10].…”

Section: Resultsmentioning

confidence: 99%

Adult Hepatoblastoma: Systemic Review of the English Literature

Wang¹,

Liu²

2012

Dig Surg

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Aims: To review all the case reports or case series of patients with adult hepatoblastoma. Methods: A search of all case reports on adult hepatoblastoma in the English literature was performed using the PubMed database. Demographic information, clinical findings, treatment modalities and outcomes were extracted and analyzed. Results: A total of 36 English articles and 40 patients with adult hepatoblastoma were collected. All these cases were confirmed by pathological diagnosis. The median age of the 40 patients was 41.5 years, including 21 males and 19 females. Hepatitis B virus tests were positive in 6 patients, and 15 patients were positive for α-fetoprotein (AFP). Liver cirrhosis was only confirmed in 7 cases. Hepatoblastoma commonly forms a single giant mass within the liver. Twenty-three cases underwent radical liver resection, including 9 cases of comprehensive treatment. The median survival time for 27 patients with available follow-ups was 4 months; 1-year survival was 29.6%. In Cox multivariate analysis, curative liver resection was an independent prognostic factor for prolonged survival (p = 0.003). Conclusions: Curative liver resection can prolong survival. Improvements in outcome will require the development of more effective systemic therapies.

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Liver, gallbladder, extrahepatic bile ducts, and pancreas

Carriaga

Henson

1995

Cancer

400

198

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Background. The liver, gallbladder, bile ducts, and pancreas have a common embryologic origin; cancers that arise from these sites therefore are expected to share a similar spectrum of histologic types. These cancers are known for their extremely poor prognoses. Methods. Data from the Surveillance, Epidemiology, and End Results Program regarding the incidence, distribution of histologic types, stage of disease, and survival for cancers of the gallbladder (n = 4412), extrahepatic bile ducts (n = 3486), pancreas (n = 23, 116), and liver (n = 6,391) were reviewed. The most common histologic types are discussed, and the frequency of rare types is reported. Results. The incidence of biliary cancer decreased, while the incidence of hepatic and pancreatic cancer rose slightly over the 15‐year period from 1973 to 1987. Age and sex distributions varied by histologic type. Greater than 98% of pancreatic and biliary cancers were carcinomas, and adenocarcinoma (not otherwise specified) was the most common histologic type recorded. In the liver, hepatocellular carcinoma was the most common type, followed by intrahepatic cholangiocarcinoma. The overall 5‐year relative survival rates for these cancers were very low: gallbladder, 12.3%; extrahepatic bile duct, 12.7%; liver 3.1%; and pancreas 2.5% (all stages combined, 1978‐1986). Conclusions. This review confirmed that these carcinomas are associated with a very poor outcome; however, survival was influenced by stage of disease and histologic type. In the gallbladder and extrahepatic bile ducts, papillary adenocarcinoma was associated with the best outcome of all histologic types, and in the exocrine pancreas, mucinous cystadenocarcinoma was associated with the best prognosis.

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Epithelial and mixed hepatoblastoma in the adult

Cited by 41 publications

References 15 publications

Recurrence of hepatocellular carcinoma as a mixed hepatoblastoma after liver transplantation

Recurrence of hepatocellular carcinoma as a mixed hepatoblastoma after liver transplantation

Adult Hepatoblastoma: Systemic Review of the English Literature

Liver, gallbladder, extrahepatic bile ducts, and pancreas

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