2015
DOI: 10.5966/sctm.2014-0287
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Abstract: Chronic rotator cuff (RC) tears are a common and debilitating injury, characterized by dramatic expansion of adipose tissue, muscle atrophy, and limited functional recovery. The role of adipose expansion in RC pathology is unknown; however, given the identified paracrine/endocrine regulation by other adipose depots, it likely affects tissue function outside its boundaries. Therefore, we characterized the epimuscular (EM) fat depot of the human rotator cuff, defined its response to RC tears, and evaluated its i… Show more

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Cited by 26 publications
(30 citation statements)
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“…RNA was extracted from harvested grafts, quantified, reverse transcribed, and transcripts detected as described previously . The primer sets for the genes of interest are listed in Supplemenary Table 1.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…RNA was extracted from harvested grafts, quantified, reverse transcribed, and transcripts detected as described previously . The primer sets for the genes of interest are listed in Supplemenary Table 1.…”
Section: Methodsmentioning
confidence: 99%
“…In support of this hypothesis, differences in the characteristics of EMAT and IMAT have been noted with injury and disease. Specifically, our recent work demonstrates that EMAT in the human rotator cuff exhibits transcriptional features of beige fat which are reduced in injured shoulders . Similarly, progenitors isolated from healthy human limb muscle have beige characteristics that are not observed in those from obese individuals .…”
mentioning
confidence: 90%
“…Progressive fat accumulation and fibrosis in RC tears at the whole‐muscle level is indisputable, but the cell population(s) responsible remain unresolved. Further complicating our understanding of fat accumulation mechanisms is the finding that lipid‐filled cells accumulate in distinct locations (epimuscular, interfascicular, and intrafascicular) within the muscle structure, where lipid in different anatomical locations may be the result of disparate cellular processes or cell populations. SCs are theoretically capable of adopting an adipogenic fate, and the lipid content of mature muscle fibers is known to increase with tear .…”
Section: Multipotent Progenitors − Potential Sources Of Fat and Fibrosismentioning
confidence: 99%
“…115,116 Multipotent adipose stem cells (ASCs) have also been implicated in fat accumulation, particularly at the epimuscular border. 110 In this region, adjacent to existing fat depots, there is evidence that RC tear leads to a whitening of the normally beige epimuscular fat depot, with implications for paracrine signaling that may affect muscle regeneration. 110 Yet fat accumulation does not strictly proceed from the muscle border, particularly in more advanced disease.…”
Section: Multipotent Progenitors à Potential Sources Of Fat and Fibrosismentioning
confidence: 99%
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