Epilepsy in Adults

International Recommendations for the Management of Adults Treated With Ketogenic Diet Therapies

“…Overall, the panel reported that the most common side effects encountered in adult patients on KDTs include (in descending order) constipation, weight loss, hyperlipidemia, leg cramps, menstrual irregularity (in women of child-bearing age), 35,36 nausea, and vomiting. Side effects noted rarely or never within each institution included gallstones, orthostatic hypotension, osteopenia/osteoporosis, and nephrolithiasis.…”

International Recommendations for the Management of Adults Treated With Ketogenic Diet Therapies

“…Overall, the panel reported that the most common side effects encountered in adult patients on KDTs include (in descending order) constipation, weight loss, hyperlipidemia, leg cramps, menstrual irregularity (in women of child-bearing age), 35,36 nausea, and vomiting. Side effects noted rarely or never within each institution included gallstones, orthostatic hypotension, osteopenia/osteoporosis, and nephrolithiasis.…”

Acetazolamide in Treatment of Epilepsy

“…It has long been known that starvation may help in reducing the frequency of epileptic seizures (Guelpa and Marie, 1911). On the assumption that ketosis and acidosis were responsible, the ketogenic diet was introduced and in some hands proved of value (Barborka, 1930;Keith, 1947). Cohen and Cobb (1941) had similar success with a sulphonamide used for the same purpose on the grounds that it inhibited the enzyme carbonic anhydrase, Which catalyses the reversible reaction CO2 + H207 H2CO3.…”

Regulation of Ketone Body Metabolism and the Role of PPARα

“…In 1920, refractory epilepsia in children was treated in such a way with considerable success [114,115]. Currently, the ketogenic diet is an adjunct therapy of choice, supporting the pharmacological treatment of epilepsy, or as a principal treatment method in drug-resistant cases, highlighting the efficacy in decreasing seizure frequency, especially in children [116,117].…”

International Recommendations for the Management of Adults Treated With Ketogenic Diet Therapies

“…Overall, the panel reported that the most common side effects encountered in adult patients on KDTs include (in descending order) constipation, weight loss, hyperlipidemia, leg cramps, menstrual irregularity (in women of child-bearing age), 35,36 nausea, and vomiting. Side effects noted rarely or never within each institution included gallstones, orthostatic hypotension, osteopenia/osteoporosis, and nephrolithiasis.…”

Acetazolamide in Treatment of Epilepsy

“…It has long been known that starvation may help in reducing the frequency of epileptic seizures (Guelpa and Marie, 1911). On the assumption that ketosis and acidosis were responsible, the ketogenic diet was introduced and in some hands proved of value (Barborka, 1930;Keith, 1947). Cohen and Cobb (1941) had similar success with a sulphonamide used for the same purpose on the grounds that it inhibited the enzyme carbonic anhydrase, Which catalyses the reversible reaction CO2 + H207 H2CO3.…”

Regulation of Ketone Body Metabolism and the Role of PPARα

“…In 1920, refractory epilepsia in children was treated in such a way with considerable success [114,115]. Currently, the ketogenic diet is an adjunct therapy of choice, supporting the pharmacological treatment of epilepsy, or as a principal treatment method in drug-resistant cases, highlighting the efficacy in decreasing seizure frequency, especially in children [116,117].…”

International Recommendations for the Management of Adults Treated With Ketogenic Diet Therapies

“…Overall, the panel reported that the most common side effects encountered in adult patients on KDTs include (in descending order) constipation, weight loss, hyperlipidemia, leg cramps, menstrual irregularity (in women of child-bearing age), 35,36 nausea, and vomiting. Side effects noted rarely or never within each institution included gallstones, orthostatic hypotension, osteopenia/osteoporosis, and nephrolithiasis.…”

Acetazolamide in Treatment of Epilepsy

“…It has long been known that starvation may help in reducing the frequency of epileptic seizures (Guelpa and Marie, 1911). On the assumption that ketosis and acidosis were responsible, the ketogenic diet was introduced and in some hands proved of value (Barborka, 1930;Keith, 1947). Cohen and Cobb (1941) had similar success with a sulphonamide used for the same purpose on the grounds that it inhibited the enzyme carbonic anhydrase, Which catalyses the reversible reaction CO2 + H207 H2CO3.…”

Regulation of Ketone Body Metabolism and the Role of PPARα

“…In 1920, refractory epilepsia in children was treated in such a way with considerable success [114,115]. Currently, the ketogenic diet is an adjunct therapy of choice, supporting the pharmacological treatment of epilepsy, or as a principal treatment method in drug-resistant cases, highlighting the efficacy in decreasing seizure frequency, especially in children [116,117].…”