Epigenetics in Oral Health

Hughes, Toby

doi:10.1007/978-3-030-50123-5_24

Cited by 1 publication

(2 citation statements)

References 81 publications

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Section: Changing Paradigms: Environmental Exposures Influence the Oral Microbiome Trajectory And Pediatric Dental Caries Riskmentioning

confidence: 99%

“…More light has been shed by studies on twins who despite similar genetic background showed different caries risk, [96] and a possible discordance correlated with methylation profile. [97] In order to examine the role of the environment in the acquisition and development of the oral microbiome, studies that are nested within a population structure designed to also control for or measure the influence of the host genome are significantly more powerful than those from randomly ascertained population probands. Such studies include traditional twin designs, parent-offspring dyads, and other genetically informative structures.…”

Section: Host Genetics Interacts With the Environment And Oral Healthmentioning

confidence: 99%

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How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?

et al. 2021

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The first 1000 days of life, from conception to 2 years, are a critical window for the influence of environmental exposures on the assembly of the oral microbiome, which is the precursor to dental caries (decay), one of the most prevalent microbially induced disorders worldwide. While it is known that the human microbiome is susceptible to environmental exposures, there is limited understanding of the impact of prenatal and early childhood exposures on the oral microbiome trajectory and oral health. A barrier has been the lack of technology to directly measure the foetal "exposome", which includes nutritional and toxic exposures crossing the placenta. Another barrier has been the lack of statistical methods to account for the high dimensional data generated by-omic assays. Through identifying which early life exposures influence the oral microbiome and modify oral health, these findings can be translated into interventions to reduce dental decay prevalence.

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Section: Changing Paradigms: Environmental Exposures Influence the Oral Microbiome Trajectory And Pediatric Dental Caries Riskmentioning

confidence: 99%

Section: Host Genetics Interacts With the Environment And Oral Healthmentioning

confidence: 99%

How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

Epigenetics in Oral Health

Cited by 1 publication

References 81 publications

How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?

How does the early life environment influence the oral microbiome and determine oral health outcomes in childhood?

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