volume 192, issue 5, P2326-2338 2014
DOI: 10.4049/jimmunol.1301758
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Thomas J. Gross, Karol Kremens, Linda S. Powers, Brandi Brink, Tina Knutson, Frederick E. Domann, Robert A. Philibert, Mohammed M. Milhem, Martha M. Monick

Abstract: Macrophages, including alveolar macrophages, are primary phagocytic cells of the innate immune system. Many studies of macrophages and inflammation have been done in mouse models, where inducible nitric oxide synthase (NOS2) and nitric oxide (NO) are important components of the inflammatory response. Human macrophages, in contrast to mouse macrophages, express little detectable NOS2 and generate little NO in response to potent inflammatory stimuli. The human NOS2 gene is highly methylated around the NOS2 tran…

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