Bo Han, Xiangqi Meng, Hui Chen, Lingchao Chen, Xing Liu, Hongjun Wang, Daming Liu, Fei Gao, Lin Lin, Jianguang Ming, Bo Sun, Shi Yin, Ruijia Wang, Pengfei Wu et al.
Abstract:Glioblastoma is the most malignant type of brain tumor, and its high invasiveness and multiplication severely shortens patients’ overall survival. The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. We used computational target gene prediction, in vitro cell culture, immunoblotting, quantitative real-time PCR, ATP measurements, luciferase reporter assays, wound-healing assays, Transwell assays, RNA immunoprecipitation PCR, co-immunoprecipitation, flow cytometry and tumor xenogr…
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