Epigenetic Response to Mindfulness in Peripheral Blood Leukocytes Involves Genes Linked to Common Human Diseases

Garcı́a-Campayo, Javier; Puebla‐Guedea, Marta; Labarga, Alberto; Urdánoz, Amaya; Roldán, Miren; Pulido, Laura; Morentin, Xabier Martínez de; Perdones-Montero, Álvaro; Montero-Marín, Jesús; Mendioroz, Maite

doi:10.1007/s12671-017-0851-6

Cited by 31 publications

(31 citation statements)

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“…As mention above, these genomic spots were found to be differentially methylated in meditators compared to controls in our previous work 35 . In the present study, DNA methylation levels at the GPR31 gene were positively correlated to telomere length.…”

Section: Discussionsupporting

confidence: 56%

“…Relationship between DNA methylation levels and telomere length. From our genome-wide DNA methylation differential analysis between long-term MMs and controls 35 , we selected the group of 14 DMRs located in subtelomeric regions, involving chromosomes 2, 4, 5, 6, 7, 8, 16, 19, and 20. We define subtelomeric regions as those regions at either end of each chromosome with a length of 3000 kb.…”

Section: Resultsmentioning

confidence: 99%

“…GPR31 (G protein-coupled receptor 31) encodes a high-affinity cell membrane receptor for 12-S-HETE, which is an arachidonic acid metabolite secreted by platelets and tumor cells that induces endothelial cell retraction and plays a role in extravasation and metastasis 62 . Notably, GPR31 has been proposed as a target of oncology therapies since GPR31 mediates KRAS (Kirsten rat sarcoma viral oncogene homolog) membrane association 35,63 , an important mechanism of tumorigenesis. More recently, GPR31 was reported to underlie hepatic ischemia-reperfusion injury 64 .…”

Section: Discussionmentioning

confidence: 99%

“…Information on participants´ meditation experience was also assessed, including the number of months that the participants had practiced meditation throughout their lifetime. The procedure and inclusion and exclusion criteria, along with socio-demographic, psychological, and health-related questionnaires, have been described elsewhere 35 .…”

Section: Participantsmentioning

confidence: 99%

“…In line with other reports, our group previously observed a positive relationship between meditation practice and longer telomere length in peripheral blood cells 13 . Moreover, in a previous work to gain insight into the molecular mechanisms of meditation, we profiled genome-wide DNA methylation changes in long-term meditators and identified a set of 64 differentially methylated regions (DMRs), corresponding to 43 genes, when compared to controls 35 . Almost half of the DMRs (48.4%) were directly linked to common human diseases, including neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.…”

mentioning

confidence: 99%

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Telomere length correlates with subtelomeric DNA methylation in long-term mindfulness practitioners

Mendioroz

Puebla‐Guedea

Montero-Marín

et al. 2020

Sci Rep

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Mindfulness and meditation techniques have proven successful for the reduction of stress and improvement in general health. In addition, meditation is linked to longevity and longer telomere length, a proposed biomarker of human aging. Interestingly, DNA methylation changes have been described at specific subtelomeric regions in long-term meditators compared to controls. However, the molecular basis underlying these beneficial effects of meditation on human health still remains unclear. Here we show that DNA methylation levels, measured by the Infinium HumanMethylation450 BeadChip (Illumina) array, at specific subtelomeric regions containing GPR31 and SERPINB9 genes were associated with telomere length in long-term meditators with a strong statistical trend when correcting for multiple testing. Notably, age showed no association with telomere length in the group of long-term meditators. These results may suggest that long-term meditation could be related to epigenetic mechanisms, in particular gene-specific DNA methylation changes at distinct subtelomeric regions.

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Section: Discussionsupporting

confidence: 56%

Section: Resultsmentioning

confidence: 99%