Epigenetic regulations in hematopoietic Hox code

He, Huiying; Hua, Xianxin; Yan, Jizhou

doi:10.1038/onc.2010.484

Cited by 32 publications

(27 citation statements)

References 124 publications

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“…Loss of the PRC2 (EZH2)-dependent epigenetic mark H3K27me 3 , and/or gain of H3K4me 3 associated with the Hoxa9 locus correlate with Hoxa9 expression (26,27). Consistent with diminished Ezh2 expression in bone marrow cultured with FLT3L or GM-CSF and MT-CM, H3K27me 3 associated with the Hoxa9 locus (11) was decreased at amplicon A in FLT3L and GM-CSF cultures (Fig.…”

Section: Esupporting

confidence: 56%

Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells

et al. 2013

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Cancer is associated with immune dysfunction characterized by the presence of proinflammatory and immunosuppressive cells and factors that contribute to tumor growth and progression. Here we show that mammary tumor growth is associated with defects in hematopoiesis, leading to myeloproliferative-like disease (leukemoid reaction), anemia, and disruption of the bone marrow stem/progenitor compartment. The defects we characterized included impaired erythropoiesis, leukocytosis, loss of early progenitor cells in the bone marrow, and splenic extramedullary hematopoiesis. We established an in vitro model to dissect interactions between mammary cancers and the hematopoietic system. Investigations in this model revealed that granulocyte colonystimulating factor (G-CSF) produced by mammary tumors can synergize with FLT3L and granulocyte macrophage CSF (GM-CSF) to expand myeloid progenitors and their progeny in culture. Mammary tumor growth was associated with histone methylation changes within lineage-negative c-Kit-positive hematopoietic cells within the bone marrow of tumor-bearing mice. Similarly, parallel histone methylation patterns occurred in cultured bone marrow cells exposed to mammary tumor-conditioned cell culture media. Notably, changes in histone methylation in these cell populations correlated with dysregulated expression of genes controlling hematopoietic lineage commitment and differentiation, including Hox family genes and members of the Polycomb repressive complex 2 (PRC2) chromatin-remodeling complex. Together, our results show that mammary tumor-secreted factors induce profound perturbations in hematopoiesis and expression of key hematopoietic regulatory genes.

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Section: Esupporting

confidence: 56%

Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells

et al. 2013

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“…HOX genes encode DNA binding proteins central in embryonic development and hematopoiesis, and their expression is epigenetically regulated by PcG and Trithorax proteins. 37 They are highly enriched in our cohort in DMC 1 and DMC 2 (supplemental Table 4). HOX genes are overexpressed in AML with mixed lineage leukemia translocations, which is a marker of poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks

Deneberg

Guardiola

Lennartsson

et al. 2011

Blood

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“…The spectrum ranges from carcinomas of epithelial origin to gastrointestinal stromal tumor of stromal origin [9, 43, 52]. Surprisingly dysregulated expression of HOTAIR has not been reported in hematological malignancies in which the HOX genes are frequently dysregulated [53, 54]. An intriguing phenomenon in breast cancer is that the established tumor cell lines exhibit a much lower expression of HOTAIR than the tumor tissues [9, 21–51].…”

Section: Expression Of Hotair In Cancermentioning

confidence: 99%

lincRNA HOTAIR as a Novel Promoter of Cancer Progression

Loewen

Zhuo

Zhuang

et al. 2014

J. Can. Res. Updates

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Large intergenic non-coding RNAs (lincRNA) regulate development and disease via interactions with their protein partners. Expression of the lincRNA HOX transcript antisense RNA (HOTAIR) is elevated in a variety of malignancies and linked to metastasis and poor prognosis. HOTAIR promotes proliferation, invasion, and metastasis in the preclinical studies of cancer through modulation of chromatin modifying complexes. In the current review we discuss the molecular mechanisms of HOTAIR-mediated aggressive phenotypes of cancer, HOTAIR’s potential in cancer intervention, and challenges in exploration of HOTAIR in cancer biology.

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Epigenetic regulations in hematopoietic Hox code

Cited by 32 publications

References 124 publications

Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells

Dysregulated Hematopoiesis Caused by Mammary Cancer Is Associated with Epigenetic Changes and Hox Gene Expression in Hematopoietic Cells

Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks

lincRNA HOTAIR as a Novel Promoter of Cancer Progression

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