Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions

Mossel, Dieuwertje M; Moganti, Kondaiah; Riabov, Vladimir; Weiß, Christel; Kopf, Stefan; Cordero, Julio; Dobreva, Gergana; Rots, Marianne G.; Klüter, Harald; Harmsen, Martin C.; Kzhyshkowska, Julia

doi:10.3389/fimmu.2020.01071

Cited by 43 publications

(40 citation statements)

References 101 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, hyperglycemia was found to induce production of pro-inflammatory cytokines and S100 proteins in human primary macrophages [234][235][236]. One of major pro-inflammatory cytokines is IL-1beta that has a complex role in tumors and promotes tumorigenesis, tumor invasiveness and immunosuppression [237,238].…”

Section: The Key Metabolic Features Of M1 Macrophagesmentioning

confidence: 99%

“…S100A9 and S100A12 that are induced by high glucose in primary human macrophages have multiple cellular targets and link inflammatory processes in cancer [239]. We have recently demonstrated that hyperglycemia induces activating histone code on the promoters of these genes in primary human macrophages, that shows that there is a link between glycolytic metabolism and the epigenetic level of regulation in macrophages [236]. However, it remains to be understood how these processes interact in TAMs.…”

Section: The Key Metabolic Features Of M1 Macrophagesmentioning

confidence: 99%

See 1 more Smart Citation

Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages

Larionova

Kazakova

Patysheva

et al. 2020

Cancers

Self Cite

View full text Add to dashboard Cite

Macrophages are key innate immune cells in the tumor microenvironment (TME) that regulate primary tumor growth, vascularization, metastatic spread and tumor response to various types of therapies. The present review highlights the mechanisms of macrophage programming in tumor microenvironments that act on the transcriptional, epigenetic and metabolic levels. We summarize the latest knowledge on the types of transcriptional factors and epigenetic enzymes that control the direction of macrophage functional polarization and their pro- and anti-tumor activities. We also focus on the major types of metabolic programs of macrophages (glycolysis and fatty acid oxidation), and their interaction with cancer cells and complex TME. We have discussed how the regulation of macrophage polarization on the transcriptional, epigenetic and metabolic levels can be used for the efficient therapeutic manipulation of macrophage functions in cancer.

show abstract

Section: The Key Metabolic Features Of M1 Macrophagesmentioning

confidence: 99%

Section: The Key Metabolic Features Of M1 Macrophagesmentioning

confidence: 99%

Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages

Larionova

Kazakova

Patysheva

et al. 2020

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…An upcoming upliftment is immediately required for a proper systematic understanding of the differences in predispositions of genetics among different populations, that undergoes patho-physiological mechanisms. Hence, a foremost Table 1 Antidiabetic drugs for COVID-19 diabetic complication (Honce and Schultz-Cherry 2019;Almond et al 2020;Dixon and Peters 2020;Wan et al 2020;Hoffmann et al 2020;Li et al 2017;Spiegel et al 1983;Zhu et al 2020) informative and knowledgeable research in this relationship and in its management must be warranted. All over the world, in more than 200 countries or territories, there exists greater than 14,650,000 confirmed cases, with more than 600,000 deaths.…”

Section: Future Prospects and Conclusionmentioning

confidence: 99%

Uncurtaining the effect of COVID-19 in diabetes mellitus: a complex clinical management approach

Kashyap¹,

Bala

Madaan

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

The aim of the present review is to overview the common properties of corona virus and hence proofs well beginning of corona virus in persons with diabetes, and its treatment. Globally, it has been observed that according to the statistics, India has the second largest number of people with diabetes. Literature review has been implemented within the databases using suitable keywords. For persons suffering from diabetic disorder, the COVID-19 infection becomes a dual challenge. Diabetes is a severe metabolic situation which causes the sugar levels in the blood to increase than the normal level. Normally, communicable disease like COVID-19 is more prevailing in patients with diabetes. Diabetic patient has poor immune response to infections. The different bacterial, viral, parasitic, and mycotic infections showed increased probability in diabetic patients as compared to non-diabetic patient. All these conclusions clear out the intention that the diabetic patients are more susceptible to enhanced inflammatory response that may lead to rapid spreading of COVID-19 infection with high rate of mortality. In the present situation of pandemic, managing diabetes seems to be quite challenging and diabetic patient having COVID-19 infection should follow normal course of antihypertensive and antidiabetic drugs prescribed with the exception of sodium glucose co-transpoters-2 inhibitors which would increase the risk of dehydration and ketoacidosis. In view of above discussion, this article highlights the proposed mechanism of COVID-19 infection linking it with diabetes, antidiabetic drugs to be used in COVID-19 infection along with their advantages, and disadvantages and management of COVID-19 infection diabetic patient.

show abstract

“…Focusing on human macrophages, a distinct study reported that hyperglycemia increased the expression of S100A8 and S100A9 in macrophages and that expression of another S100/calgranulin, S100A12 (or EN-RAGE, a ligand of the receptor for advanced glycation end products [RAGE]) [ 35 ], was sustained in human macrophages after glucose levels were returned to euglycemia [ 36 •]. Mechanistically, it was found that hyperglycemia increased the acetylation of histones which were bound to the S100A9 and S100A12 promoters in the “M1” or pro-inflammatory macrophages in processes involving SMYD3 and SET7/9 [ 36 •].…”

Section: Epigenetics: Long-lasting Memory and Consequences To The Cardiovascular Systemmentioning

confidence: 99%

Diabetes and Cardiovascular Complications: The Epidemics Continue

et al. 2021

View full text Add to dashboard Cite

Purpose of Review The cardiovascular complications of type 1 and 2 diabetes are major causes of morbidity and mortality. Extensive efforts have been made to maximize glycemic control; this strategy reduces certain manifestations of cardiovascular complications. There are drawbacks, however, as intensive glycemic control does not impart perennial protective benefits, and these efforts are not without potential adverse sequelae, such as hypoglycemic events. Recent Findings Here, the authors have focused on updates into key areas under study for mechanisms driving these cardiovascular disorders in diabetes, including roles for epigenetics and gene expression, interferon networks, and mitochondrial dysfunction. Updates on the cardioprotective roles of the new classes of hyperglycemia-targeting therapies, the sodium glucose transport protein 2 inhibitors and the agonists of the glucagon-like peptide 1 receptor system, are reviewed. Summary In summary, insights from ongoing research and the cardioprotective benefits of the newer type 2 diabetes therapies are providing novel areas for therapeutic opportunities in diabetes and CVD.

show abstract

Epigenetic Regulation of S100A9 and S100A12 Expression in Monocyte-Macrophage System in Hyperglycemic Conditions

Abstract: code on the respective gene promoters in M1 macrophages. Mechanistically, this regulation relies on action of histone methyltransferases SMYD3 and SET7/9. The results define an important role for epigenetic regulation in macrophage mediated inflammation in diabetic conditions.

Cited by 43 publications

References 101 publications

Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages

Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages

Uncurtaining the effect of COVID-19 in diabetes mellitus: a complex clinical management approach

Diabetes and Cardiovascular Complications: The Epidemics Continue

Contact Info

Product

Resources

About