Marja C.J.A. van Eggermond, Daniël R. Boom, Petra Klous, Erik Schooten, Victor E. Marquez, Rutger J. Wierda, Tjadine M. Holling, Peter J. van den Elsen
Abstract:In humans, T-cells accomplish expression of MHC-II molecules through induction of CIITA upon activation. Here we show that CIITA promoter accessibility in T-cells is epigenetically regulated. In unstimulated T-cells, CIITA-PIII chromatin displays relative high levels of repressive histone methylation marks (3Me-K27-H3 and 3Me-K20-H4) and low levels of acetylated histones H3 (Ac-H3) and H4 (Ac-H4). These repressive histone marks are replaced by histone methylation marks associated with transcriptional active ge…
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