Epigenetic modifications of human placenta associated with preterm birth: a systematic review

Toure, Drissa; ElRayes, Wael; Barnes–Josiah, Debora; Hartman, Teresa; Klinkebiel, David; Baccaglini, Lorena

doi:10.1080/14767058.2017.1291620

Cited by 14 publications

(9 citation statements)

References 24 publications

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“…On the other hand, excessive stress reduced the recovery process with deteriorated symptoms. Concentration of immoderate mechanical stress may induce fatigue fractures or periprosthetic fractures [27]. Similarly, optimal mechanical stimulation was suggested to impede osteoarthritis progression, while increased stress may exacerbate osteoarthritis in contract [28].…”

Section: Discussionmentioning

confidence: 99%

Proper mechanical stress promotes femoral head recovery from steroid-induced osteonecrosis in rats through the OPG/RANK/RANKL system

Qin

Yang

et al. 2020

BMC Musculoskelet Disord

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Background: Long-term use of steroid may lead to osteonecrosis of the femoral head (ONFH). Mechanical stress may help bone formation and remodeling. This study aimed to probe the role of mechanical stress in the femoral head recovery in rats. Methods: Rat models with ONFH were induced by steroid. Rats were subjected to different levels of mechanical stress (weight-bearing training), and then the morphology and bone density of femoral head of rats were measured. The mRNA and protein levels of the OPG/RANK/RANKL axis in rat femoral head were assessed. Gain-and loss-of function experiments of OPG were performed to identify its role in femoral head recovery following stress implement. The ex vivo cells were extracted and the effects of stress and OPG on osteogenesis in vitro were explored. Results: Steroid-induced ONFH rats showed decreased bone density and increased bone spaces, as well as necrotic cell colonies and many cavities in the cortical bones and trabeculars. Proper mechanical stress or upregulation of OPG led to decreased RANK/RANKL expression and promoted femoral head recovery from steroid-induced osteonecrosis. However, excessive mechanical stress might impose too much load on the femurs thus leading even retard femoral head recovery process. In addition, the in vitro experimental results supported that proper stress and overexpression of OPG increased the osteogenesis of ex vivo cells of femoral head. Conclusion: This study provided evidence that proper mechanical stress promoted femoral head recovery from steroid-induced osteonecrosis through the OPG/RANK/RANKL system, while overload might inhibit the recovery process. This study may offer novel insights for ONFH treatment.

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Section: Discussionmentioning

confidence: 99%

Proper mechanical stress promotes femoral head recovery from steroid-induced osteonecrosis in rats through the OPG/RANK/RANKL system

Qin

Yang

et al. 2020

BMC Musculoskelet Disord

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“…1). The scarcely available literature explains these pregnancy-associated conditions as a result of foetal epigenetics modifications, thus limiting or leading to aberrant expression of several genes including those involved in cell growth, inflammation, oxidative stress, D-glucose metabolism, among others [6,7]. The use of techniques such as wide-genome arrays and bisulfite pyrosequencing are allowing fast forward identification of foetal epigenetic modifications.…”

Section: Discussionmentioning

confidence: 99%

Foetoplacental epigenetic changes associated with maternal metabolic dysfunction

et al. 2018

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“…It mainly involves insulin resistance in these individuals. Additionally, it also involves a gut-microbiota interaction, the “cross-talk.” It deals with preterm birth itself 47) , infant neurodevelopment 48 49) , and pulmonary outcomes 50) . It also confers definite inflammatory traits in the intestine in preterm infants, and can result in high susceptibility to NEC.…”

Section: Microbiome-related Epigeneticsmentioning

confidence: 99%

Fetal and preterm infant microbiomes: a new perspective of necrotizing enterocolitis

Choi

Song

2017

Korean J Pediatr

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Necrotizing enterocolitis (NEC) is a devastating condition of hospitalized preterm infants. Numerous studies have attempted to identify the cause of NEC by examining the immunological features associated with pathogenic microorganisms. No single organism has proven responsible for the disease; however, immunological studies are now focused on the microbiome. Recent research has investigated the numerous bacterial species residing in the body and their role in diseases in preterm infants. The timing of initial microbial colonization is a subject of interest. The microbiome appears to transfer from the mother to the newborn, as well as to the fetus. Cross-talk between the fetus and fetal microbiome takes place continuously to generate a unique immune system. This review examined the transfer of the microbiome to the human fetus, and its potential relationship with NEC.

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Epigenetic modifications of human placenta associated with preterm birth: a systematic review

Cited by 14 publications

References 24 publications

Proper mechanical stress promotes femoral head recovery from steroid-induced osteonecrosis in rats through the OPG/RANK/RANKL system

Proper mechanical stress promotes femoral head recovery from steroid-induced osteonecrosis in rats through the OPG/RANK/RANKL system

Foetoplacental epigenetic changes associated with maternal metabolic dysfunction

Fetal and preterm infant microbiomes: a new perspective of necrotizing enterocolitis

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