2016
DOI: 10.18632/aging.100906
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Abstract: 5XFAD is an early-onset mouse transgenic model of Alzheimer disease (AD). Up to now there are no studies that focus on the epigenetic changes produced as a result of Aβ-42 accumulation and the possible involvement in the different expression of related AD-genes. Under several behavioral and cognition test, we found impairment in memory and psychoemotional changes in female 5XFAD mice in reference to wild type that worsens with age.Cognitive changes correlated with alterations on protein level analysis and gene… Show more

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Cited by 74 publications
(85 citation statements)
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References 54 publications
(53 reference statements)
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“…In our cell culture studies, Ab 42 promoted a decrease in the nuclear levels of DNMT1, although DNMT3a and DNMT3b were unaffected. Cerebral levels of DNMT1 have been shown to be reduced in AD mouse models (62,63). However, we did not observe a decrease in the methylation of the RELN promoter, either in frontal cortex from patients with AD or in our cell culture studies.…”
Section: Discussioncontrasting
confidence: 88%
“…In our cell culture studies, Ab 42 promoted a decrease in the nuclear levels of DNMT1, although DNMT3a and DNMT3b were unaffected. Cerebral levels of DNMT1 have been shown to be reduced in AD mouse models (62,63). However, we did not observe a decrease in the methylation of the RELN promoter, either in frontal cortex from patients with AD or in our cell culture studies.…”
Section: Discussioncontrasting
confidence: 88%
“…Rostral portions of freshly dissected brain hemispheres (including the hippocampus) were cut (350 mm) sequentially using a 3000 Vibratome (Thermo Fisher Scientific, Waltham, MA, USA) in oxygenated low-Ca 2+ artificial cerebrospinal fluid (ACSF, 0.1 mM Ca 2+ ). Slices containing dorsal hippocampus were then placed in an interface-type chamber and maintained in oxygenated regular ACSF at 32°C for at least 2 h. Regular ACSF contains the following (mM): NaCl (128), KCl (3), CaCl (2), MgCl (2), glucose (10), KH 2 PO 4 (1.25), and NaHCO 3 (26). Individual slices were transferred one at a time to a microscope stage (E600 FN; Nikon, Tokyo, Japan) equipped with a recording chamber continuously perfused (2 ml/min) with oxygenated ACSF maintained at ;32°C (TC2Bip; Cell Micro Controls, Norfolk, VA, USA).…”
Section: Hippocampal Electrophysiology (Ahp)mentioning
confidence: 99%
“…Aldehyde dehydrogenase 2 mice are also called HNE mice because they exhibit a greater‐than‐normal hippocampus concentration of the peroxidation product HNE (the earliest evidence for oxidative stress in patients with prodromal AD (30), together with spatial learning and memory impairments and age‐dependent spontaneous AD‐like histopathology (17). 5xFAD mice are a common β‐amyloidogenic model of familial AD that demonstrates hippocampus oxidative stress (including HNE accumulation) and spatial cognitive defects (26, 28). UBE3A ‐knockout mice are a model of AS, a genetic neurodevelopmental disorder characterized by hippocampus oxidative stress and impaired goal location based on external cues and other endophenotypes consistent with that in patients with AS (2, 31).…”
mentioning
confidence: 99%
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“…For example, elevated levels of TNFα are observed in serum and cerebrospinal fluid from AD patients compared to age-matched controls [44, 45]. Similarly, overexpression of TNFα has been shown in several animal models of AD, including the 3xTg-AD and 5XFAD mouse models [11, 46, 47]. More importantly, increased TNFα in AD models has been correlated with disease progression [48].…”
Section: Discussionmentioning
confidence: 99%