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Cited by 4 publications
(13 citation statements)
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References 9 publications
(13 reference statements)
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“…For full evaluation, this may require single-cell bisulfite sequencing (scBS-seq) studies, nanopore sequencing analysis, and further technological advancement to be fully realized (discussed in “Challenge 5”). These tissue- and disease-specific clocks in isolated cell types or cell type-aware analyses could enable greater insights into the molecular drivers of biological aging [97]. These processes need to be explored across all organ systems, to identify not only specific but also common mechanisms.…”
Section: Challengementioning
confidence: 99%
“…For full evaluation, this may require single-cell bisulfite sequencing (scBS-seq) studies, nanopore sequencing analysis, and further technological advancement to be fully realized (discussed in “Challenge 5”). These tissue- and disease-specific clocks in isolated cell types or cell type-aware analyses could enable greater insights into the molecular drivers of biological aging [97]. These processes need to be explored across all organ systems, to identify not only specific but also common mechanisms.…”
Section: Challengementioning
confidence: 99%
“…To date, many other DNA methylation clocks have been developed for different purposes and tissue targets. 3,4,618 Since their inception, epigenetic clocks have been used to analyze DNA methylation profiles of diverse human cohorts, uncovering previously unknown associations between accelerated ageing and a great number of health-related features. 19,20 These associations indicate that epigenetic clocks do not just track chronological age, but also biological features that are relevant to the ageing process.…”
Section: Introductionmentioning
confidence: 99%