2018
DOI: 10.1159/000491431
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Abstract: DNA methylation patterns change with age and can be used to derive an estimate of “epigenetic age,” an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated biological aging. This study examined associations between estimated epigenetic age and various variables in 160 male combat-exposed war veterans with (n = 79) and without PTSD (n = 81). DNA methylation was assessed i… Show more

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Cited by 36 publications
(32 citation statements)
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“…The methylation status of certain CpG sites within these genes could explain individual variability in response to paroxetine treatment [86]. Verhoeven et al's 2018 study of veterans with and without PTSD introduced the idea that antidepressant medications may have a global effect on DNA methylation patterns that alter one's epigenetic age [88]. The long-term effects of these medications on not only depression but general medical health are yet to be explored [88].…”
Section: Discussionmentioning
confidence: 99%
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“…The methylation status of certain CpG sites within these genes could explain individual variability in response to paroxetine treatment [86]. Verhoeven et al's 2018 study of veterans with and without PTSD introduced the idea that antidepressant medications may have a global effect on DNA methylation patterns that alter one's epigenetic age [88]. The long-term effects of these medications on not only depression but general medical health are yet to be explored [88].…”
Section: Discussionmentioning
confidence: 99%
“…Global DNA methylation patterns and methylation at certain sites correlate with biological age in humans [87]. This "epigenetic aging" was studied in 160 male combat-exposed veterans to investigate whether there was a difference in epigenetic age between subjects with and without post-traumatic stress disorder (PTSD) (n = 79; n = 81) [88]. Verhoeven et al 2018 discovered that PTSD subjects counterintuitively had a younger epigenetic age than subjects without PTSD.…”
Section: Global Dna Methylationmentioning
confidence: 99%
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“…Specifically, telomere length has been most extensively researched and was found to be shorter in various somatic conditions 8 , all-cause mortality 9,10 and a range of psychiatric disorders 11 . Advanced epigenetic age has also been linked to worse somatic health, mortality 12 , depressive disorder 7,13 and post-traumatic stress disorder 14 , although some studies have found associations with the opposite direction of effect 15,16 . Advanced transcriptomic age was found in those with higher blood pressure, cholesterol levels, fasting glucose, and body mass index (BMI) 17 .…”
Section: Introductionmentioning
confidence: 99%