Epidural anesthesia and analgesia in horses

Robinson, Elaine P.; Natalini, Cláudio Corrêa

doi:10.1016/s0749-0739(02)00010-x

Cited by 74 publications

(117 citation statements)

References 32 publications

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“…The authors’ findings describing the sedative qualities of romifidine and detomidine in buffalo are similar to those reported in cattle and goats after epidural administration of α 2 -adrenoceptor agonists (Caron and LeBlanc 1989, Zaugg and Nussbaum 1990, Prado and others 1999, Fierheller and others 2004, Kinjavdekar and others 2006). Sedation occurs following the absorption of epidurally administered drugs into the vascular system (Gomez De Segura and others 1993, Robinson and Natalini 2002) or transfer from the cerebral spinal fluid (Pedraz and others 1991). …”

Section: Discussionmentioning

confidence: 99%

Comparative antinociceptive and sedative effects of epidural romifidine and detomidine in buffalo (Bubalus bubalis)

Marzok

El-Khodery

2017

Veterinary Record

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In this study, comparative antinociceptive and sedative effects of epidural administration of romifidine and detomidine in buffalo were evaluated. Eighteen healthy adult buffalo, allocated randomly in three groups (two experimental and one control; n=6) received either 50 μg/kg of romifidine or detomidine diluted in sterile saline (0.9 per cent) to a final volume of 20 ml, or an equivalent volume of sterile saline epidurally. Antinociception, sedation and ataxia parameters were recorded immediately after drug administration. Epidural romifidine and detomidine produced mild to deep sedation and complete antinociception of the perineum, inguinal area and flank, and extended distally to the coronary band of the hindlimbs and cranially to the chest area. Times to onset of antinociception and sedation were significantly shorter with romifidine than with detomidine. The antinociceptive and sedative effects were significantly longer with romifidine than with detomidine. Romifidine or detomidine could be used to provide a reliable, long-lasting and cost-effective method for achieving epidural anaesthesia for standing surgical procedures in buffalo. Romifidine induces a longer antinociceptive effect and a more rapid onset than detomidine. Consequently, epidural romifidine may offer better therapeutic benefits in the management of acute postoperative pain.

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Section: Discussionmentioning

confidence: 99%

Comparative antinociceptive and sedative effects of epidural romifidine and detomidine in buffalo (Bubalus bubalis)

Marzok

El-Khodery

2017

Veterinary Record

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“…Sedation occurs following the absorption of epidurally administrated drugs into the vascular system (Gomez De Segura and others 1993, Robinson and Natalini 2002) or transfer from the cerebral spinal fluid (Pedraz and others 1991). …”

Section: Discussionmentioning

confidence: 99%

Dose‐dependent antinociceptive and sedative effects of epidural romifidine in cattle

Marzok

El-Khodery

2016

Veterinary Record

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The objective of this study was to evaluate the antinociceptive and sedative effects of epidural administration of romifidine in dairy cattle. Twenty-four dairy cows, divided randomly into four groups (three experimental and one control; n=6) received one of three doses of romifidine (30, 40 or 50 μg/kg) diluted in sterile saline (0.9 per cent) to a final volume of 25 ml or an equivalent volume of sterile saline. Antinociception and its anatomical extent was assessed by applying a standard stimulus (needle pin pricks) in different areas and by applying an electrical stimulus to the flank. The antinociceptive effect of romifidine was produced not only in the tail, anus, perineum, vulva and inguinal area but extended up to the coronary band of the hindlimbs and chest areas. Epidural romifidine induced mild-to-moderate sedation at 30 and 40 μg/kg doses and deep sedation at the 50 μg/kg dose. The antinociceptive and sedative effect was dose-dependent in terms of intensity and duration. Thus, epidural administration of romifidine was effective in providing antinociception and sedation in cattle, and can be used in standing flank and udder surgery in cattle.

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Section: Discussionmentioning

confidence: 99%

“…In horses, epidural morphine (0.1 mg/kg) was considered a useful alternative for long-term relief of pain, with a duration of action of about eight hours and a low incidence of cardiopulmonary and neurological side effects (Valverde and others 1990, Robinson and others 1993). Epidural morphine reduced surgical time during laparoscopic standing ovariectomy and was shown to be useful in the management of perineal and lumbosacral pain in horses (Robinson and others 1993, Natalini and Robinson 2000, Van Hoogmoed and Galuppo 2005, Van Loon and others 2012). Pruritus and mild decreases in gastrointestinal motility, without causing complete ileus or colic, have been recorded as minimal adverse reactions after epidural administration of morphine (Haitjema and Gibson 2001, Burford and Corley 2006, Sano and others 2011, Martin-Flores and others 2014).…”

Section: Discussionmentioning

confidence: 99%

Continuous caudal epidural analgesia for perioperative pain control after bilateral mastectomy in a mare

Rodrigo-Mocholí

Steblaj

Vlaminck

et al. 2016

Vet Record Case Reports

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An epidural catheter was used to provide perioperative analgesia as part of a multimodal balanced anaesthesia and analgesia in a mare undergoing a bilateral mastectomy. Despite development of severe hypoxaemia during anaesthesia, recovery from anaesthesia was uneventful. Oral administration of a NSAID combined with administration of xylazine and morphine by an epidural catheter resulted in adequate postoperative pain relief, based on assessment of physiological parameters and behaviour. Neither complications nor side effects were observed during hospitalisation.

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Epidural anesthesia and analgesia in horses

Cited by 74 publications

References 32 publications

Comparative antinociceptive and sedative effects of epidural romifidine and detomidine in buffalo (Bubalus bubalis)

Comparative antinociceptive and sedative effects of epidural romifidine and detomidine in buffalo (Bubalus bubalis)

Dose‐dependent antinociceptive and sedative effects of epidural romifidine in cattle

Continuous caudal epidural analgesia for perioperative pain control after bilateral mastectomy in a mare

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