Epidermotropic urothelial carcinoma involving the glans penis

Paget's Disease of the Gians penis: An Unusual Urological Malignancy

“…Originally local spread via an intra-epithelial route seemed unlikely as our patient had had a total urethrectomy as a primary procedure; however, the re sected urethral specimen had TCC within it and spread could have occurred, with the tumour cells being dormant for 3 years. This long latent period before any sign of the Paget's lesion appears is common to other cases [5,6], TCC with radiotherapy and then cysto-urethrectomy with removal of glans pagetoid lesion; he was found subsequently to have an underlying peri-urethral gland adenocarcinoma, to explain the Paget's lesion Thus, intra-epidermal spread appears a possible explana tion of pagetoid lesions, but we cannot rule out seeding of exfoliated cells. De novo tumour arising in a different epi thelium from the original tumour seems an unlikely prop osition.…”