Epidermotropic metastatic squamous cell carcinoma. Report of two cases showing histologic continuity between epidermis and metastasis

Weidner, N.

doi:10.1001/archderm.121.8.1041

Cited by 11 publications

(9 citation statements)

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“…Clinically, in-transit metastases from cutaneous SCC are mostly subcutaneous or dermal papules with occasional exophytic features 4 13 . The 2 cases reported by Weidner and Foucar 14 were SCC of the lower lip and hand that had in-transit metastases to the submental region of the skin and an upper extremity, respectively. Meanwhile, Copcu et al 13 report 2 cases of in-transit cutaneous metastasis with an acantholytic pattern from a skin tumor on the face.…”

Section: Discussionmentioning

confidence: 99%

Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review

et al. 2015

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Marjolin's ulcer is an aggressive cutaneous malignancy common in previously traumatized or chronically inflamed skin. It has high regional metastasis and fatality rates. Our patient presented with subcutaneous nodules and ulcerations on the right limb. He had a history of osteomyelitis of the fifth toe. Histopathological examination of the nodule and ulceration demonstrated squamous cell carcinoma. The nodules and ulcerations were in-transit metastases of Marjolin's ulcer. Here, we present a case of squamous cell carcinoma arising at a site of a chronic osteomyelitis with resultant in-transit metastases.

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Section: Discussionmentioning

confidence: 99%

Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review

et al. 2015

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“…15,25 It has been postulated that this phenomenon is due to the natural tendency of squamous epithelial cells to repair a denuded epithelial surface. 26 Clues to identifying primary versus secondary SCC include evidence of malignant cells in blood and/or lymphatic vessels and multiple cutaneous lesions appearing synchronously. 18 In this case, there was histopathologic evidence of malignant cells in lymphatic vessels concurrent with the presentation of multiple skin lesions.…”

Section: Discussionmentioning

confidence: 99%

Epidermotropic metastasis from vulvar squamous cell carcinoma: A rare cutaneous manifestation

Wang

O’Brien

Ross

et al. 2010

Journal of the American Academy of Dermatology

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“…15,16 It is not inconceivable that this epithelial repopulation and fusion mechanism could also apply to a benign lesion such as endometriosis. Indeed, repopulation of adenomyosis in the uterus by endometrial carcinoma is a common finding.…”

Section: Discussionmentioning

confidence: 99%

Colonization of Intestinal Endometriosis by Benign Colonic Mucosa: A Pattern Potentially Misdiagnosed as Invasive Mucinous Carcinoma

Tipps

Weidner

2010

Int J Surg Pathol

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Endometriosis is well known for creating diagnostic pitfalls for pathologists. It may produce masses mimicking neoplasms or cause diagnostic quandaries, particularly when the patient age, location, and/or epithelial appearance are atypical. This study reports a patient with endometriosis causing rectal bleeding and involving the cecum. It produced a mass clinically considered appendiceal. The endometriosis was focally lined by intestinal epithelium including Paneth cells. In the deep endometriotic glands embedded within intestinal wall, direct fusion of the intestinal and the endometrial epithelium-the benign intestinal epithelium apparently colonizing the endometriotic foci-was found. The mass effect, plus deep-seated intestinal epithelium, closely mimicked invasive well-differentiated mucinous carcinoma. This is yet another peculiar presentation of endometriosis with potential for misinterpretation as a more serious condition, specifically well-differentiated mucinous carcinoma of the cecum or appendix.

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Epidermotropic metastatic squamous cell carcinoma. Report of two cases showing histologic continuity between epidermis and metastasis

Cited by 11 publications

References 0 publications

Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review

Marjolin's Ulcer Presenting with In-Transit Metastases: A Case Report and Literature Review

Epidermotropic metastasis from vulvar squamous cell carcinoma: A rare cutaneous manifestation

Colonization of Intestinal Endometriosis by Benign Colonic Mucosa: A Pattern Potentially Misdiagnosed as Invasive Mucinous Carcinoma

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