Epidermotropic Metastatic Malignant Melanoma Simulating Melanoma in situ

Clonal relationships between epidermotropic metastatic melanomas and their primary lesions: a loss of heterozygosity and X-chromosome inactivation-based analysis

“…6,11 Additionally, evolving criteria for epidermotropic metastatic melanomas, such as angiotropism, maturation, and striking pagetoid spread have been described. 5,7 Thus, there is a group of epidermotropic metastatic melanomas that fit the classic description; however, there is also a group that does not, often leading to significant diagnostic challenge in differentiating a metastasis from a new primary lesion.…”

“…However, since the original description, multiple reports have described the varied histopathologic presentations of epidermotropic metastatic melanomas, proposed additional criteria, and questioned whether histopathology alone can differentiate these metastases from a new primary melanoma. [5][6][7][8][9][10][11][12] Molecular studies of melanoma and its metastases in various forms have revealed frequent genetic alterations. Traditional ideology infers that tumors result when a single transformed cell leads to a clonal population of malignant cells.…”

Epidermotropically Metastatic Pancreatic Adenocarcinoma

“…Differentiating a primary neoplasm from an epidermotropically metastatic neoplasm can be challenging, especially in regard to melanoma. 2 Epidermotropically metastatic breast carcinoma may simulate melanoma and Paget's disease. 3 Mechanistically, neoplastic cells emerge from cutaneous vessels with subsequent seeding of the epidermis or adnexal epithelium.…”

“…Clinical history serves as the most important piece of information in determining the nature of the process in these cases. 2 In cases of epidermotropically metastatic adenocarcinoma, differentiating a primary skin apocrine carcinoma from an epidermotropically visceral adenocarcinoma may be impossible in some cases without the benefit of clinical history. 4 The best-known example is the difficulty differentiating extramammary Paget's disease, a primary apocrine carcinoma of the skin, from urogenital or rectal carcinomas that extends on to the epidermis.…”

Epidermotropic Chondroid Metastasis of Melanoma: Report of a Case of Metastatic Melanoma With Previously Unreported Morphological Features

“…In the past few decades, the concept of metastatic melanoma has changed completely, [1][2][3][4][5][6][7][8][9][10] and it has been accepted that metastatic melanoma could share some morphological features with primary melanoma, mainly epidermotropism. With time, the morphologic spectrum of EMM has broadened, and its distinguishing features have become faint.…”