Epidermotropic Eccrine Carcinoma

Pinkus, Hermann; Mehregan, Amir H.

doi:10.1001/archderm.1963.01590230105015

Cited by 268 publications

(86 citation statements)

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“…EPC was described as a separate entity in 1963 by Pinkus and Mehregan [21]. It is considered a rare tumor with an estimated incidence in Europe of less than 0.3/ 100,000; to date a total of 300 cases have been reported in the literature [22,23,24].…”

Section: Discussionmentioning

confidence: 99%

Clinical, Dermoscopic and Histopathological Features of Eccrine Poroid Neoplasms

Sgouros

Piana²,

Argenziano

et al. 2013

Dermatology

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Background: Eccrine poroma (EP) belongs to the group of benign adnexal tumors, but cases of eccrine porocarcinoma (EPC) arising on long-standing and untreated EP suggest a certain risk of malignant transformation. Objectives: To describe the clinical, dermoscopic and histopathologic features associated with different extremes in the spectrum of eccrine poroid neoplasms and to review the according literature. Methods: A retrospective analysis of patient characteristics and morphologic features associated with EP, EPC in situ and invasive porocarcinoma patients who attended two skin lesion clinics in Italy and Turkey between 2010 and 2011. Results: A total of 4 cases including 1 EP, 1 EPC in situ and 2 cases of invasive EPC in 4 patients were analyzed. Recent changes including bleeding, ulceration and sudden enlargement of a pre-existing lesion were associated with malignant transformation. Dermoscopically, polymorphous vessels consisting of coiled, hairpin and linear vessels were seen at all stages of progression. Histopathological findings of EPC in situ were limited to the epidermal component and were evident only at higher magnification. Conclusions: Clinicians and pathologists should carefully evaluate EPs with a recent history of change and erosion in order to avoid overlooking the potential development of EPC.

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Section: Discussionmentioning

confidence: 99%

Clinical, Dermoscopic and Histopathological Features of Eccrine Poroid Neoplasms

Sgouros

Piana²,

Argenziano

et al. 2013

Dermatology

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“…Histopathologically, one can readily dis tinguish between an eccrine poroma and other benign skin lesions such as a verruca vulgaris, a granuloma pyogenicum, a fibro ma, a dermatofibroma, a papillomatous nevocytic nevus (occasionally pigmented), a hemangioma, and scar tissue (possibly with telangiectasia) [10,13,19,23,24], On the basis of the occurrence of, striking ly, only centrally located cytologic atypical ities with dyskeratosis and the increased in cidence of mitoses without signs of invasive growth or spread, the tumors of the second group can be interpreted as dysplastic vari ants of the eccrine poroma ( fig. 3).…”

Section: Discussionmentioning

confidence: 99%

The Histology of Eccrine Poromas: A Study of 14 Cases

Pylyser¹,

Wolf‐Peeters²,

Mariën

1983

Dermatology

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A histological study of 14 eccrine poromas in 14 different patients was conducted and the results correlated with the clinical data. Histologically, an eccrine poroma is an easily recognizable epithelial skin tumor. Three morphological variants can be identified: a benign, a premalignant or dysplastic, and an invasive, malignant form. These tumors hardly have a typical clinical appearance. Symptoms such as bleeding, pain and itching are suggestive of a possible malignant transformation. There seems to be a predilection for localization on the limbs and the head. Most of the lesions occur in patients above the age of 60. It is noteworthy that these tumors, at least those of the face, occur on actinically damaged areas.

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“…Jadassohn [9], 22 years later, reported that he consid ered a basal-cell carcinoma which was exclusively intraepi dermal. Since then, the terms Borst-Jadassohn phenomenon or intraepidermal epithelioma of Borst-Jadassohn have been used to designate a heterogeneous group of neoplasms including both benign and malignant entities [10][11][12]: seb orrheic keratosis, junctional nevus, verrucous epidermal nevus, Bowen's disease, solar keratosis, malignant mela noma, epidermotropie metastatic carcinoma, mammary and extramammary Paget's disease, histiocytosis X and Merkel cell tumor [20].…”

Section: Discussionmentioning

confidence: 99%