Epidermolysis Bullosa of the Newborn

Epidermolysis Bullosa Hereditaria Letalis (Herlitz)

“…4. This has been previously reported by several authors (Lamb andHalper, 1947, andSchaffer, 1951). The absence or reduced am ount of elastic tissue in the upper coriiim was also dem onstrated in this case by the elastic tissue stain.…”

Epidermolysis Bullosa Hereditaria `Letalis': Report of a Case Surviving for Two-and-a-half Years

“…Engman and Mook (1906), Matheson andRosner (1949), Siemans (1937) and Schaffer (1951) also concluded that the superficial layers of the skin contained deficient elastic tissue, while Leland and Hirschl (1954) observed degeneration of the collagen fibrils of the skin. On the other hand Lamb and Halpert (1947) found the hair follicles, sebaceous and sweat glands and collagenous bundles in the skin to be normal, and Lewis, Steven and Farquhar (1955) noted apparently normal elastic elements in two fatal cases.…”

Epidermolysis Bullosa in the Newborn

“…Since Herlitz's paper other examples of this fatal form have been described (Davidson, 1940;Brandberg, 1941;Schroder and Wells, 1945;Black, Wilhelm, Gilbert and White, 1945;Lamb and Halpert, 1947;Matheson and Rosner, 1949;Schaffer, 1951;Kagen, Williams, Giffen and Wiley, 1952;and Leland and Hirschl, 1954). The paper by Leland and Hirschl stated that before their own paper, which added two further examples, 32 patients with epidermolysis bullosa hereditaria letalis had been reported in the world literature but clinical features as well as the pathology have differed from the details given by Herlitz.…”

“…Herlitz (1935) mentioned that the skin was thinner than usual with degenerated elastic fibres and rudimentary hair follicles and sweat glands. Lamb and Halpert (1947) stated that the corium was loose, fibrillar and relatively acellular, but they mentioned that normal collagenous bundles, hair follicles, sebaceous and sweat glands were present. Normal skin glands were mentioned by Schaffer (1951) but he found a thin epidermal layer, and, while the amount of elastic tissue was reduced, the elastic filaments were not entirely atrophied.…”