Epidermolysis Bullosa Acquisita (Tardive) and Porphyria Cutanea Tarda

Epidermolysis Bullosa Acquisita

“…The hemorrhagic bullae, scarring, milia forma-tion, nail changes, and hair loss agree with the descriptions of EBA offered by Wise and Lautman 4 and Epstein et al 8 The differential diag¬ nosis of a scarring bullous disease of the extremities must include porphyria cutánea tarda, but the normal urine and stool porphyrin values and the bullae under the breasts eliminate this consideration in our patient. The hemorrhagic bullae, scarring, milia forma-tion, nail changes, and hair loss agree with the descriptions of EBA offered by Wise and Lautman 4 and Epstein et al 8 The differential diag¬ nosis of a scarring bullous disease of the extremities must include porphyria cutánea tarda, but the normal urine and stool porphyrin values and the bullae under the breasts eliminate this consideration in our patient.…”

Epidermolysis Bullosa Acquisita-a Sign of Cicatricial Pemphigoid?

“…Subepidermal blister formation with histological separation at the dermo-epidermal junction is of course consistent with both BP and CP as well as other blistering diseases. Splitting of the PASpositive basement membrane was first described in EBA by Epstein, Epstein & Greenlee (1959). It is a feature which has been frequently quoted since then in connection with EBA and was found in six of seven patients in the present series.…”

Case Report : Epidermolysis Bullosa Acquisita

“…The basement membrane splitting shown in two of the three cases of Eoenigk et al (1971) and also by Sasai (1965) and Epstein et al (1959) is seen in this case. It is suspected that this may be where the primary defect arises (Epstein et al, 1959).…”