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Cited by 346 publications
(215 citation statements)
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References 24 publications
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“…EGFR Signaling Pathway in Cancer Progression EGFR, a surface receptor with intrinsic tyrosine kinase activity, is one of several known pivotal intermediates in many epithelial malignancies (37). It belongs to the erbB growth factor receptor family.…”
Section: Chemoprevention For Hncmentioning
confidence: 99%
“…EGFR Signaling Pathway in Cancer Progression EGFR, a surface receptor with intrinsic tyrosine kinase activity, is one of several known pivotal intermediates in many epithelial malignancies (37). It belongs to the erbB growth factor receptor family.…”
Section: Chemoprevention For Hncmentioning
confidence: 99%
“…Our previous study found that co-expression of EGFR and HER2 was observed in approximately 90% of primary human esophageal squamous cell carcinoma. Therefore, the EGFR family is an attractive candidate target for cancer therapy and many different EGFRtargeted molecular treatments have been attempted, such as anti-receptor monoclonal antibodies, anti-ligand monoclonal antibodies, ligand-toxin conjugates, scFv-toxin conjugates, ligand-genistein conjugates and tyrosine kinase inhibitors (21). Several studies and our previous study suggest that combined treatment with drugs that target EGFR and HER2 might result in efficient inhibition of tumor growth in breast cancer, head and neck cancer, and epidermoid and esophageal carcinomas (22,23).…”
Section: Introductionmentioning
confidence: 99%
“…Iressa, an orally active, selective EGFR tyrosine kinase inhibitor, has shown an antiproliferative effect on a wide variety of solid tumors. [26][27][28] Both in vitro and in vivo preclinical studies 29,30 have shown a lack of correlation between EGFR expression levels and a response to Iressa. However, receptor phosphorylation levels do, in fact, appear to play a key role in Iressa activity.…”
Section: Discussionmentioning
confidence: 99%