Epidermal expression of HLA-DR antigens in mycosis fungoides

Tjernlund, U

doi:10.1007/bf00455380

Cited by 81 publications

(22 citation statements)

References 11 publications

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“…It is possible, however, that the staining pattern seen in the present study represents HLA-DR expression on normal keratinocyte membranes. Expression of HLA-DR antigen has been reported on keratinocyte membranes in diseased tissues (21,(37)(38)(39).…”

Section: Discussionmentioning

confidence: 99%

Pattern of distribution of T lymphocytes, Langerhans cells and HLA‐DR bearing cells in normal human oral mucosa

Reibel

Dabelsteen

et al. 1985

European J Oral Sciences

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– The tissue distribution of helper/inducer and suppressor/cytotoxic T cells, Langerhans cells (LC) and HLA‐DR bearing cells was determined in normal oral mucosa by use of monoclonal antibodies OKT4, OKT8, OK.T6 and OKIal, respectively. OKT4+ and OKT8+ cells were invariably present in normal oral epithelium and in the lamina propria. OKT8+ cells were consistently seen inside the basal cell layer of the epithelium. The distribution of LC in oral epithelium showed regional variation. In palatal epithelium LC were evenly distributed in the basal half of the epithelium, whereas in buccal mucosa the highest concentration of LC was seen in the epithelium overlying the tips of connective tissue papillae. OKIal stained dendritic cells in the epithelium and plump cells with small dendritic processes in the connective tissue. Some of the latter were located close to the basal cells of the epithelium. The consistent relationship between immunocompetent cells and the epithelium of the oral mucosa suggests the presence of a local immunologic defence barrier in the oral mucosa.

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Section: Discussionmentioning

confidence: 99%

Pattern of distribution of T lymphocytes, Langerhans cells and HLA‐DR bearing cells in normal human oral mucosa

Reibel

Dabelsteen

et al. 1985

European J Oral Sciences

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“…Looking at our enzymocytochemical slides it is evident how numerous the indeterminate cells and the Langerhans' cells are, for both show a diffusely distributed a-naphthyl acetate esterase activity. From the literature we know that there are not only morphological and enzymological similarities between indeterminate cells and Langerhans' cells, but that many similarities exist in the receptors: Fc-IgG and C, are demonstrated in both cells, both have la antigens [27] and HLA-DR antigens [38] on their surface.…”

Section: Discussionmentioning

confidence: 99%

Microenvironment of Woringer-Kolopp’s Disease

1982

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A localized form of ‘Pagetoid reticulosis’ (Woringer-Kolopp’s disease) is described morphologically. It can be shown that ultrastructurally the ‘Pagetoid cells’ are heterogenic and that different cell types can be distinguished: there are lymphoid cells, which often look like Lutzner cells, and nonlymphoid cells which can be characterized as indeterminate cells or Langerhans’ cells. Often a close topographical relation between lymphoid and nonlymphoid cells can be demonstrated. This finding is suggestive for a functional interaction between the lymphoid cells, which are most probably T cells, and indeterminate cells and Langerhans’ cells, which are known to be important for the thymus-dependent immune reaction. The presence of the nonlymphoid cell population in the epidermis in Woringer-Kolopp’s disease seems to build up the specific microenvironment for lymphoid cell reaction.

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“…Although HLA-DR or class II major histocompatibility (MHC) antigens have generally been related to cells of the immune system, recent studies have revealed the presence of HLA-DR antigens on cells not definitely known to serve immunological functions; one of these cell types is the keratinocyte. While in normal skin HLA-DR antigen is confined to Langerhans cells (Stingl, Tamaki & Katz, 1980) and acrosyringial epithelial cells (Murphy et al, 1983), in a number of skin disorders (Aiba& Tagami, 1984;Lampert, 1984;SmoUe, 1985) including graftvs-host disease (Lampert et aL, 1982), lichen planus (Tjernlund, 1980), mycosis fungoides (Tjernlund, 1978), allergic contact dematitis (MacKie & Turbitt, 1983) and alopecia areata (Messenger et aL, 1984) keratinocytes synthesize (Volc-Platzer et al, 1984) and express HLA- Thyroid follicular epithelial cells have been reported to bear HLA-DR antigen in Graves' disease, whereas they are HLA~DR-negative in the normal state )-It has been suggested that 'aberrant' expression of MHC class H antigens on these cells might play an important role in the initiation and perpetuation of immune reactions . Similar views have been voiced regarding the skin (Nickoloff et al, 1985).…”

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confidence: 99%

HLA-DR expression on keratinocytes is a common feature of diseased skin

et al. 1986

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Biopsy specimens from 185 patients with 52 different skin disorders were investigated by indirect immunofluorescence staining for the presence of HLA-DR bearing keratinocytes and their association with an underlying inflammatory infiltrate and in particular with activated (HLA-DR-positive, Leu-4-positive) T lymphocytes. HLA-DR expression on keratinocytes was demonstrated in 38 dermatoses, including lymphocytic vasculitis, lupus erythematosus, morphea, vitiligo, lichen planus, cutaneous T-cell lymphoma, various infectious dermatoses, allergic contact dermatitis, granulomatous dermatoses, Sweet's syndrome, lichen sclerosus and erythema nodosum. In 27 of these this had not previously been reported. Occurrence of HLA-DR on keratinocytes was invariably linked to the presence of a lymphocytic infiltrate containing numerous activated T-cells (Leu-4 +, HLA-DR +) whereas such infiltrates were not accompanied by HLA-DR expression on keratinocytes in all the dermatoses investigated, as in pseudolymphoma and erythema anulare centrifugum. However, HLA-DR positive keratinocytes were consistently absent in skin disorders lacking any significant lymphocytic infiltration (e.g. leukocytoclastic vasculitis, bullous autoimmune dermatoses, genodermatoses and mastocytosis). Although it has been suggested that HLA-DR-positive keratinocytes are involved in various immune responses of the skin, their exact functional significance is, as yet, unknown.

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Epidermal expression of HLA-DR antigens in mycosis fungoides

Cited by 81 publications

References 11 publications

Pattern of distribution of T lymphocytes, Langerhans cells and HLA‐DR bearing cells in normal human oral mucosa

Pattern of distribution of T lymphocytes, Langerhans cells and HLA‐DR bearing cells in normal human oral mucosa

Microenvironment of Woringer-Kolopp’s Disease

HLA-DR expression on keratinocytes is a common feature of diseased skin

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